Background: Angiogenesis is tightly linked to inflammation. Cytokines of
interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.
Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in
mediating inflammation-induced angiogenesis.
Results: The results showed that the angiogenesis was attenuated by topical
administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal
neovascularization (CNV). Further study showed that the expression of inflammatory
cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas.
Moreover, the angiogenic activities including the proliferation, migration and tube
formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro.
Conclusion: The data indicate that IL-38 modulates inflammation-induced