The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization

Author(s): Jiangli Zhu, Jing Zhang, Yan Wang, Jianping Chen, Xiaopeng Li, Xiangling Liu, Eryan Kong, Shao B. Su*, Zhongjian Zhang*.

Journal Name: Current Molecular Medicine

Volume 19 , Issue 8 , 2019

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Abstract:

Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.

Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.

Results: The results showed that the angiogenesis was attenuated by topical administration of IL-38 to the injured corneas in a mouse model of alkali-induced corneal neovascularization (CNV). Further study showed that the expression of inflammatory cytokines TNF-α, IL-6, IL-8 and IL-1β was decreased in the IL-38-treated corneas. Moreover, the angiogenic activities including the proliferation, migration and tube formation of human retinal endothelial cells were reduced by IL-38 treatment in vitro.

Conclusion: The data indicate that IL-38 modulates inflammation-induced angiogenesis.

Keywords: Angiogenesis, cytokine, interleukin, inflammation, IL-38, neovascularization.

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VOLUME: 19
ISSUE: 8
Year: 2019
Page: [589 - 596]
Pages: 8
DOI: 10.2174/1566524019666190627122655
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