Bivalirudin Versus Heparin During Intervention in Acute Coronary Syndrome: A Systematic Review of Randomized Trials

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Author(s): Sukhdeep Bhogal, Debabrata Mukherjee, Jayant Bagai, Huu Tam Truong, Hemang B. Panchal, Ghulam Murtaza, Mustafa Zaman, Rajesh Sachdeva, Timir K. Paul*.

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets

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Abstract:

Introduction: Bivalirudin and heparin are the two most commonly used anticoagulants used during percutaneous coronary intervention (PCI). The results of randomized controlled trials (RCTs) comparing bivalirudin versus heparin monotherapy in the era of radial access are controversial, questioning the positive impact of bivalirudin on bleeding. The purpose of this systematic review is to summarize the results of RCTs comparing the efficacy and safety of bivalirudin versus heparin with or without glycoprotein IIb/IIIa inhibitors (GPI).

Methods: This systematic review was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements for reporting systematic reviews. We searched the National Library of Medicine PubMed, Clinicaltrial.gov and the Cochrane Central Register of Controlled Trials to include clinical studies comparing bivalirudin with heparin in patients undergoing PCI. Sixteen studies met inclusion criteria and were reviewed for summary.

Findings: Several RCTs and meta-analyses have demonstrated the superiority of bivalirudin over heparin plus routine GPI use in terms of preventing bleeding complications but at the expense of increased risk of ischemic complications such as stent thrombosis (ST). The hypothesis of post- PCI bivalirudin infusion to mitigate the risk of acute ST have been tested in various RCTs with conflicting results. In comparison, heparin offers advantage of availability of reversible agent, less cost and reduced incidence of ischemic complications.

Conclusion: Bivalirudin demonstrates its superiority over heparin plus GPI with better clinical outcomes in terms of preventing bleeding complications, thus making it as an anticoagulation of choice particularly in patients at high risk of bleeding. Further studies are warranted for head to head comparison of bivalirudin to heparin monotherapy to establish an optimal heparin dosing regimen and post-PCI bivalirudin infusion to affirm its beneficial effect in reducing acute ST.

Keywords: Heparin, Bivalirudin, Glycoprotein IIb/IIIa inhibitors, Percutaneous coronary intervention, Bleeding events, Stent thrombosis

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(E-pub Ahead of Print)
DOI: 10.2174/1871529X19666190626124057

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