Latent Tuberculosis Infection (LTBI) and Its Potential Targets: An Investigation into Dormant Phase Pathogens

(E-pub Ahead of Print)

Author(s): Gopichand Gutti, Karan Arya, Sushil Kumar Singh*.

Journal Name: Mini-Reviews in Medicinal Chemistry

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Abstract:

One-third of the world’s population harbours the latent tuberculosis infection (LTBI) with a lifetime risk of reactivation. Although the treatment of LTBI relies significantly upon first-line therapy, identification of novel drug targets and therapies are the emerging focus for researchers across the globe. The current review provides insights about the infection, diagnostic methods and epigrammatic explanations of some potential molecular targets of dormant phase bacilli. This study also includes current preclinical and clinical aspects of tubercular infections and new approaches in tubercular drug discovery

Keywords: Latent tuberculosis infection, diagnosis, biomarkers, molecular targets, Mtb topoisomerase-I, lysine 3-aminotransferase, isocitrate lyase, regulon

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389557519666190625165512
Price: $95

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