Neprilysin: A Potential Therapeutic Target of Arterial Hypertension?

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Author(s): Juan Salazar*, Joselyn Rojas Quintero, Climaco Cano, Jose L Perez, Paola Ramirez, Ruben Carrasquero, Wheeler Torres, Cristobal Espinoza, Maricarmen Chacín González, Valmore Bermudez.

Journal Name: Current Cardiology Reviews

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Abstract:

Arterial hypertension is the most prevalent chronic disease in the adult population of developed countries and it constitutes a significant risk factor in the development of cardiovascular disease, contributing to the emergence of many comorbidities, among which heart failure excels, a clinical syndrome that nowadays represents a major health problem with uncountable hospitalizations and whose indolent course progressively worsens until quality of life decreases and lastly death is found prematurely. In the light of this growing menace, each day more effort is invested in the field of cardiovascular pharmacology, searching for new therapeutic options that allow us to modulate the physiologic systems that are corrupted among these pathologies, therefore in the latter years the study of natriuretic peptides has become so relevant, which mediates beneficial effects at the cardiovascular level such as diuresis, natriuresis, and decreasing cardiac remodeling, their metabolism is mediated by neprilysin a metalloproteinase widely expressed in the human and capable of catalyzing many substrates. The modulation of these functions has been studied by decades, giving room to Sacubitril the first neprilysin inhibitor which in conjunction with an angiotensin receptor blocker has provided a high efficacy and tolerability among patients with heart failure, for who it has already been approved and recommended. Nonetheless, in the matter of arterial hypertension, significant findings have arisen that demonstrate the potential role that it will play between the pharmacological alternatives of the upcoming years.

Keywords: arterial hypertension, heart failure, neprilysin, natriuretic peptides, sacubitril, pharmacology

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(E-pub Ahead of Print)
DOI: 10.2174/1573403X15666190625160352

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