Circulating Factors and Ultrasono-findings are Linked to Previous Atherosclerotic Burden and Recurrent Risk

Author(s): Kyoung J. Cho, Jihye Kim, Soung H. Jeon, Gyung W. Kim*.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 12 , 2019

Abstract:

Background: In the progression of atherosclerosis, platelet activation and the interaction of platelets with leukocytes play a crucial role in arterial thrombus formation and are associated with the pathophysiology of carotid and cerebrovascular disease (CVD), including ischemic stroke. With aged participants, we evaluated and followed up the change in circulating factor and platelet-leukocyte aggregate levels in participants with or without CVD history. This study investigated whether circulating factor changes and ultrasonographic characteristics link to CVD risk and other relating long-term outcomes.

Materials and Methods: Two hundred fifteen participants who enrolled in the study were divided into two groups with CVD and without CVD history. We evaluated and analyzed the correlation between ultrasonography-based morphological characteristics and circulating factor-based functional changes in both groups.

Results: There was no difference in p-selectin level between both groups. However, activated monocyte and platelet-monocyte aggregate levels were higher in patients with previous CVD than without previous CVD. Circulating factor and ultrasonographical characteristics were correlated in the group with CVD, whereas these factors were not correlated in the group without CVD.

Conclusion: We found that circulating blood factor levels showed a different tendency in participants with and without CVD history. The results depict that atherosclerotic severity might depend on the history of CVD and progression of atherosclerosis. We suggest that the circulating factor levels, atherosclerotic severity, and history of CVD are considered in the observation of pathologic progression to manage the development of CVD risks and CVD relating outcomes.

Keywords: Circulating factors, atherosclerosis, platelet monocyte-aggregation, p-selectin, Mac-1, ultrasonography, cerebrovascular disease.

[1]
Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, Miyamoto Y. Impact of intima-media thickness progression in the common carotid arteries on the risk of incident cardiovascular disease in the suita study. J Am Heart Assoc 2018; 7(11): e007720. [http://dx.doi.org/10.1161/JAHA.117.007720]. [PMID: 29858361].
[2]
Cho K, Kim J, Kim GW. Changes in blood factors and ultrasound findings in mild cognitive impairment and dementia. Front Aging Neurosci 2017; 9: 427. [http://dx.doi.org/10.3389/fnagi.2017.00427]. [PMID: 29311909].
[3]
Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997; 96(5): 1432-7. [http://dx.doi.org/10.1161/01.CIR.96.5.1432]. [PMID: 9315528].
[4]
Tsivgoulis G, Vemmos K, Papamichael C, et al. Common carotid artery intima-media thickness and the risk of stroke recurrence. Stroke 2006; 37(7): 1913-6. [http://dx.doi.org/10.1161/01.STR.0000226399.13528.0a]. [PMID: 16728693].
[5]
Prati P, Tosetto A, Vanuzzo D, et al. Carotid intima media thickness and plaques can predict the occurrence of ischemic cerebrovascular events. Stroke 2008; 39(9): 2470-6. [http://dx.doi.org/10.1161/STROKEAHA.107.511584]. [PMID: 18617662].
[6]
Cha JK, Jeong MH, Jang JY, et al. Serial measurement of surface expressions of CD63, P-selectin and CD40 ligand on platelets in atherosclerotic ischemic stroke. A possible role of CD40 ligand on platelets in atherosclerotic ischemic stroke. Cerebrovasc Dis 2003; 16(4): 376-82. [http://dx.doi.org/10.1159/000072560]. [PMID: 13130179].
[7]
Marquardt L, Anders C, Buggle F, Palm F, Hellstern P, Grau AJ. Leukocyte-platelet aggregates in acute and subacute ischemic stroke. Cerebrovasc Dis 2009; 28(3): 276-82. [http://dx.doi.org/10.1159/000228710]. [PMID: 19609079].
[8]
Tsai NW, Chang WN, Shaw CF, et al. The value of leukocyte adhesion molecules in patients after ischemic stroke. J Neurol 2009; 256(8): 1296-302. [http://dx.doi.org/10.1007/s00415-009-5117-3]. [PMID: 19353220].
[9]
Hashimoto H, Kitagawa K, Kuwabara K, et al. Circulating adhesion molecules are correlated with ultrasonic assessment of carotid plaques. Clin Sci (Lond) 2003; 104(5): 521-7. [http://dx.doi.org/10.1042/CS20020290]. [PMID: 12570870].
[10]
Michelson AD, Barnard MR, Krueger LA, Valeri CR, Furman MI. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 2001; 104(13): 1533-7. [http://dx.doi.org/10.1161/hc3801.095588]. [PMID: 11571248].
[11]
Ritter MA, Jurk K, Schriek C, et al. Microembolic signals on transcranial Doppler ultrasound are correlated with platelet activation markers, but not with platelet-leukocyte associates: a study in patients with acute stroke and in patients with asymptomatic carotid stenosis. Neurol Res 2009; 31(1): 11-6. [http://dx.doi.org/10.1179/174313208X331590]. [PMID: 18768115].
[12]
Park HK, Chung JW, Hong JH, et al. Preceding intravenous thrombolysis in patients receiving endovascular therapy. Cerebrovasc Dis 2017; 44(1-2): 51-8. [http://dx.doi.org/10.1159/000471492]. [PMID: 28427054].
[13]
Liapis CD, Kakisis JD, Dimitroulis DA, Kostakis AG. The impact of the carotid plaque type on restenosis and future cardiovascular events: a 12-year prospective study. Eur J Vasc Endovasc Surg 2002; 24(3): 239-44. [http://dx.doi.org/10.1053/ejvs.2002.1714]. [PMID: 12217286].
[14]
Schmalbach B, Stepanow O, Jochens A, Riedel C, Deuschl G, Kuhlenbäumer G. Determinants of platelet-leukocyte aggregation and platelet activation in stroke. Cerebrovasc Dis 2015; 39(3-4): 176-80. [http://dx.doi.org/10.1159/000375396]. [PMID: 25720421].
[15]
Stone GW, Maehara A, Lansky AJ, et al. A prospective natural-history study of coronary atherosclerosis. N Engl J Med 2011; 364(3): 226-35. [http://dx.doi.org/10.1056/NEJMoa1002358]. [PMID: 21247313].
[16]
Mathiesen EB, Johnsen SH. Ultrasonographic measurements of subclinical carotid atherosclerosis in prediction of ischemic stroke. Acta Neurol Scand Suppl 2009; (189): 68-72. [http://dx.doi.org/10.1111/j.1600-0404.2009.01210.x]. [PMID: 19566503].
[17]
Htun P, Fateh-Moghadam S, Tomandl B, et al. Course of platelet activation and platelet-leukocyte interaction in cerebrovascular ischemia. Stroke 2006; 37(9): 2283-7. [http://dx.doi.org/10.1161/01.STR.0000236638.75591.61]. [PMID: 16888273].
[18]
Ogata T, Yasaka M, Yamagishi M, Seguchi O, Nagatsuka K, Minematsu K. Atherosclerosis found on carotid ultrasonography is associated with atherosclerosis on coronary intravascular ultrasonography. J Ultrasound Med 2005; 24(4): 469-74. [http://dx.doi.org/10.7863/jum.2005.24.4.469]. [PMID: 15784765].
[19]
Dotsenko O, Chaturvedi N, Thom SA, et al. Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men. J Thromb Haemost 2007; 5(10): 2036-42. [http://dx.doi.org/10.1111/j.1538-7836.2007.02711.x]. [PMID: 17883700].


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 25
ISSUE: 12
Year: 2019
Page: [1424 - 1429]
Pages: 6
DOI: 10.2174/1381612825666190620145845

Article Metrics

PDF: 25
HTML: 3