Bioactive Natural and Synthetic Peroxides for the Treatment of Helminth and Protozoan Pathogens: Synthesis and Properties

Author(s): Vera A. Vil’ , Alexander O. Terent’ev* , Olga M. Mulina .

Journal Name: Current Topics in Medicinal Chemistry

Volume 19 , Issue 14 , 2019

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Graphical Abstract:


Abstract:

The significant spread of helminth and protozoan infections, the uncontrolled intake of the known drugs by a large population, the emergence of resistant forms of pathogens have prompted people to search for alternative drugs. In this review, we have focused attention on structures and synthesis of peroxides active against parasites causing neglected tropical diseases and toxoplasmosis. To date, promising active natural, semi-synthetic and synthetic peroxides compounds have been found.

Keywords: Peroxides, Neglected tropical diseases, Schistosoma, Fasciola, Leishmania, Trypanosoma, Toxoplasma.

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