Introduction: Hepatocellular Carcinoma (HCC) is one of the most common malignant
tumors in the world and comes third in cancer-induced mortality. The need for improved and more
specific diagnostic methods that can detect early-stage disease is immense, as it is amenable to curative
modalities, while advanced HCC is associated with low survival rates. microRNA (miRNA) expression
is deregulated in HCC and this can be implemented both diagnostically and therapeutically.
Objective: To provide a concise review on the role of miRNA in diagnosis, prognosis, and treatment
Methods: We conducted a comprehensive review of the PubMed bibliographic database.
Results: Multiple miRNAs are involved in the pathogenesis of HCC. Measurement of the levels of
these miRNAs either in tumor tissue or in the blood constitutes a promising diagnostic, as well as
prognostic tool. OncomiRs are miRNAs that promote tumorigenesis, thus inhibiting them by administering
antagomiRs is a promising treatment option. Moreover, replacement of the depleted miRNAs
is another potential therapeutic approach for HCC. Modification of miRNA levels may also regulate
sensitivity to chemotherapeutic agents.
Conclusion: miRNA play a pivotal role in HCC pathogenesis and once the underlying mechanisms
are elucidated, they will become part of everyday clinical practice against HCC.