Background: The poor bioavailability of a problematic molecule is predominantly due to its
high lipophilicity, low solubility in gastric fluids and/or high fist pass metabolism. Self microemulsifying
drug delivery system (SMEDDS), a lipidic type IV nano-formulation has been of interest in the
field of pharmaceutical research due to its potential for tailoring the physicochemical properties of
Methods: This review provides insights on various recent innovations and reports from the past seven
years (2012-2019) of self-emulsifying formulations for the delivery of various types of poorly soluble
drugs, phytoconstituents and high molecular peptides and gives exhaustive details of the outcome of
the endeavors in this field.
Results: Various types of innovative formulations have been molded from SMEDDS like selfemulsifying
powders, granules, tablets, pellets, eutectic and cationic formulations. Till date, many research
reports and patents have been filed on self-emulsifying dosage forms and many formulations
have gained US-FDA approvals which are summarized in the review article.
Conclusion: This review content highlighted the increasing scope of SMEDDS in augmenting the
physiochemical properties of an API, the variegated formulation types and the attributes of API that
can be improved by SMEDD based formulations.