Secondary Metabolites from Deep-sea Derived Microorganisms

(E-pub Ahead of Print)

Author(s): Chunxiao Sun , Shah Mudassir , Zhenzhen Zhang , Yanyan Feng , Yimin Chang , Qian Che , Qianqun Gu , Tianjiao Zhu , Guojian Zhang* , Dehai Li* .

Journal Name: Current Medicinal Chemistry


Microorganisms obtained from the deep sea are a rich source of marine natural products with distinctive chemical structures and bioactivities. In this review, we will provide a retrospective of outstanding research within the scope of deep-sea (≥1000 m) microbial natural products, which has produced up to 442 compounds by the end of 2017. Approximate 60% of these structures have demonstrated various biological activities with more than 30% showing cytotoxic function. In this review, we shall particularly summarize those successful research on secondary metabolites produced by deep-sea derived microorganisms with inclusion of structural characteristics, biological activities, together with biogenetic origins and taxonomic features of the source microorganisms, from which, we expect to provide more comprehensive understanding of small molecules obtained from deep-sea environment and benefit the ongoing scholarly endeavors in searching for novel pharmaceutical agents from the deep-sea derived microorganisms.

Keywords: deep-sea-derived microorganisms; secondary metabolite; biological activity; cytotoxic; antibacterial.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/0929867326666190618153950
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