Association Between Fat-soluble Vitamins and Lipid Profile in the Overweight Population

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Author(s): Sadegh Piran, Sahar Sarmasti, Mohammad Shabani, Naser Kakavandi, Bita Hosseni, Mohsen Khosravi, Shima Resaee, Elham Soltanmohammadi, Faezeh Naseri, Ghasem Ghasempour, Asghar Mohammadi, Mohammad Najafi*.

Journal Name: Recent Patents on Food, Nutrition & Agriculture

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Methods: A total of 120 overweight subjects participated in this study. The circulating PCSK9 and vitamin D were measured by ELISA technique. The serum vitamin A and vitamin E amounts were simultaneously measured by HPLC method. The serum small dense LDL-Cholesterol (sdLDL-C) values were evaluated using heparin-Mg2+ precipitation technique. The lipid profile was measured by routine laboratory techniques. Results: The serum vitamin E values correlated significantly to vitamin A (r=0.47, P= 0.0001), VLDL-C (r= 0.30, P= 0.002), total cholesterol (r=0.309, P= 0.001), PCSK9 (r=0.233, P=0.01) and total triglyceride (r= 0.61, P= 0.0001) values. The circulating PCSK9 values correlated significantly to LDL-C (r=0.17, P=0.05) and total cholesterol (r=0.23, P=0.009) values. However, there were not correlations between the levels of serum D and A vitamins, the serum LDL-C, sdLDL-C and total cholesterol values. Conclusion: The data showed the correlations between serum vitamin E and PCSK9-related LDL-C values lower than the normal range. Furthermore, the results suggested a nutritional need on the patents considering supplementation or fortification of vitamin E for the overweight subjects with higher LDL-C levels.

Keywords: Vitamin E, Vitamin D, Vitamin A, sdLDL-C, LDL-C, PCSK9, Overweight populationVitamin E, Vitamin D, Vitamin A, sdLDL-C, LDL-C, PCSK9, Overweight population

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(E-pub Ahead of Print)
DOI: 10.2174/2212798410666190618152134