Background: Chrysin (CH) is one of the main flavonoids of vegetables, fruits, and
plants, the neuroprotective effect of which has been demonstrated in this study.
Objective: The aim of the current investigation is the evaluation of the impact of chrysin (CH) on
serum corticosterone level. Additionally, depression due to chronic stress was studied in animal
Method: The rats were restrained for 1 hour daily for 3 weeks. During these weeks, all animals
were daily injected with either vehicle or CH (10, 20, 30 μg/kg).
Results: Present data indicated that the serum corticosterone levels markedly elevated in the
stressed group versus the non-stressed group (p<0.001). The serum corticosterone levels were
significantly lower in the stress-exposed rats administered with CH versus the stress-exposed non-
CH-treated rats (p<0.05). In addition, immobility time significantly increased in the rats submitted
to restraint stress versus the non-stressed group (p<0.001). Also, the number of crossing
significantly decreased in the rats submitted to restraint stress versus non-stressed rats (p<0.001).
The immobility time and the number of crossing were also reduced in the CH-administrated
stressed rats (30 mg/kg) versus non-treated stressed group (p<0.001, p<0.05, respectively). CH also
ameliorated the MDA and GSH content as well as antioxidant enzymes activities in stressed rats
Conclusion: The present study suggested that CH might be useful for the management of
depressant-like effects induced by chronic stress via decreasing oxidative damage in the brain.