Plant Derived Natural Alkaloids as New Antimicrobial and Adjuvant Agents in Existing Antimicrobial Therapy

(E-pub Abstract Ahead of Print)

Author(s): Rajinder Pal Mittal, Vikas Jaitak.

Journal Name: Current Drug Targets

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Abstract:

Infectious diseases, instigated by pathogenic microorganisms are the cause of numerous health problems in developing countries. Infectious diseases got a place in list of top ten death causes of worldwide. The reason behind that level of severity is antimicrobial resistance. Antimicrobial resistance made the antimicrobial agents useless, that was used in the treatment of infectious diseases. Microbes very smartly achieved the resistance against synthetic and semi-synthetic antimicrobial agents for their survival. So, handling of these infectious diseases becomes very challenging. The resistance developing power is the reason, for their existence from million years. Due to their highly dangerous nature, proper treatment of these infectious diseases becomes a topic of concern. This concern leads the scientists or researchers to focus their research towards natural agents. Plants synthesize secondary metabolites are to cope up with biotic and abiotic changes in environment. Alkaloids are one of the secondary metabolite, synthesized by plants. Alkaloids protect the plant from predators and help them to fight with pathogens. Alkaloids protecting nature can be used as a strong weapon in a battle with resistant microorganisms. The purpose of this review is to provide the information about the antimicrobial activity of alkaloids attained from different plants and their combination with synthetic antimicrobials. The way of their mechanism of action against microorganism is also given in the review.

Keywords: Antimicrobials, alkaloids, inhibition, mechanisms

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/1389450120666190618124224
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