Nanoscience becomes one of the most cutting-edge research directions in recent years since it is gradually
matured from basic to applied science. Nanoparticles (NPs) and nanomaterials (NMs) play important roles in
various aspects of biomedicine science, and their influences on the environment have caused a whole range of
uncertainties which require extensive attention. Due to the quantitative and dynamic information provided for
human proteome, mass spectrometry (MS)-based quantitative proteomic technique has been a powerful tool for
nanomedicine study. In this article, recent trends of progress and development in the nanomedicine of proteomics
were discussed from quantification techniques and publicly available resources or tools. First, a variety of popular
protein quantification techniques including labeling and label-free strategies applied to nanomedicine studies are
overviewed and systematically discussed. Then, numerous protein profiling tools for data processing and postbiological
statistical analysis and publicly available data repositories for providing enrichment MS raw data information
sources are also discussed.
Keywords: Nanoproteomics, nanomaterials, nanomedicine, protein quantification, mass spectrometry, biomedicine science.
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