Microbial Bioconversion: A Regio-specific Method for Novel Drug Design and Toxicological Study of Metabolites

Author(s): Maria Yousuf*, Waqas Jamil, Khayala Mammadova.

Journal Name: Current Pharmaceutical Biotechnology

Volume 20 , Issue 14 , 2019

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Abstract:

The methods of chemical structural alteration of small organic molecules by using microbes (fungi, bacteria, yeast, etc.) are gaining tremendous attention to obtain structurally novel and therapeutically potential leads. The regiospecific mild environmental friendly reaction conditions with the ability of novel chemical structural modification in compounds categorize this technique; a distinguished and unique way to obtain medicinally important drugs and their in vivo mimic metabolites with costeffective and timely manner. This review article shortly addresses the immense pharmaceutical importance of microbial transformation methods in drug designing and development as well as the role of CYP450 enzymes in fungi to obtain in vivo drug metabolites for toxicological studies.

Keywords: Microbial bioconversion, regiospecificity, novel drugs, drug metabolites, pharmaceutical leads, CYP450 enzymes.

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Article Details

VOLUME: 20
ISSUE: 14
Year: 2019
Page: [1156 - 1162]
Pages: 7
DOI: 10.2174/1389201020666190618115821
Price: $58

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