Antioxidant Properties of Solenostemma argel Effervescent Tablets

Author(s): Rasha S. Suliman*, Heyam S. Ali, Khulud Alhelal, Wejdan Almutairi, Shahd Alnasser, Mustafa Omer, Rania Suliman, Asmaa Algebali.

Journal Name: Current Pharmaceutical Biotechnology

Volume 20 , Issue 8 , 2019

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Graphical Abstract:


Abstract:

Objective: In the present study, Solenostemma argel effervescent tablets were prepared from Argel methanolic extract.

Methods: The tablets were examined for their ability to impede carbon tetrachloride (CCl4)-induced lipid peroxidation in mice liver. The antioxidant activities of the enzymes; super-oxide dismutase (SOD), glutathione peroxidase (GS-PX) along with malondialdehyde level were tested in liver tissues.

Results: The obtained results indicated that the antioxidant enzyme activities were remarkably reduced while the level of Malondialdehyde (MDA), which shows lipid peroxidation, and the activity of alanine aminotransferase (a liver function test) were remarkably intensified following intra-peritoneal i.p injection with the single sub-lethal hepatotoxic dose of CCl4 compared to the control. A necrotic lesion in the liver of mice injected with CCl4 was observed by the histopathological examination. The damaging influence of CCl4 was improved by the retreatment with Argel or BHT, which could also be observed in the normal appearance of the liver tissue.

Conclusion: In this study, it was concluded that S. Argel and butylated hydroxytoluene (BHT) could be effective by decreasing lipid peroxidation and increasing the activities of antioxidant enzymes. Therefore, Argel might be applied as a hepatoprotective agent without any side effects.

Keywords: Solenostemma argel, effervescent tablet, butylated hydroxytoluene, carbon tetrachloride, hepatoprotective agent, Malondialdehyde (MDA).

[1]
Rysä, J.; Leskinen, H.; Ilves, M.; Ruskoaho, H. Distinct upregulation of extracellular matrix genes in transition from hypertrophy to hypertensive heart failure. Hypertension, 2005, 45(5), 927-933.
[2]
Abd El-Ghani, M.; Huerta-Martínez, F.; Hongyan, L.; Qureshi, R. Plant responses to hyperarid desert environments. Cham. Springer Int. Publish., 2017, 45(5), 927-933.
[3]
Al-Naqeb, A.G. Hypoglycemic effect and in vitro antioxidant activity of methanolic extract from Argel (Solenostemma argel) plant. Int. J. Herbal Med., 2014, 2(2), 128-131.
[4]
Hm, O.; Me, S.; Me Ahmed, M. The effect of Solenostemma argel leaves extract on status of induced lipid constituents in albino rats. Int. J. Development Res., 2015, (3), 3828-3830.
[5]
Zain, M.; Awaad, A.; Al-Outhman, M.; El-Meligy, R. Antimicrobial activities of Saudi Arabian desert plants. Inforesights Publish., 2012, 2(1), 106-113.
[6]
Eldesouky, Z.M.; Awaad, A.S.; Al-Outhman, M.R.; El-Meligy, R.M. Antimicrobial activities of Saudi Arabian desert plants. Phytopharmacology, 2012, 2(1), 106-113.
[7]
Farah, A.; Ahmed, E. Beneficial antibacterial, antifungal and anti-insecticidal effects of ethanolic extract of Solenostemma argel leaves. Mediterr. J. Biosci., 2016, 1(4), 184-191.
[8]
Al-Malki, A.L. Antioxidant properties of Solenostemma argel and butylated hydroxytoluene in carbon tetrachloride - induced mice liver injury. J. King Abdul Aziz Uni.: Sci., 2010, 22(1), 239-248.
[9]
Ibrahim, E.; Gaafar, A.; Salama, Z.; El Baz, F. Anti-inflammatory and antioxidant activity of Solenostemma argel extract. Int. J. Pharmacog. Phytochem. Res., 2015, 7(4), 635-641.
[10]
Saad El-Beltagi, H.; Abdel-Mobdy, Y.E.; Abdel-Rahim, E. Toxicological influences of cyfluthrin attenuated by Solenostemma argel extracts on carbohydrate metabolism of male albino rats. Fresenius Environ. Bull., 2017, 26(2a), 1673-1681.
[11]
Kaufman, A.; Mennin, S.; Waterman, R.; Duban, S.; Hansbarger, C.; Silverblatt, H.; Obenshain, S.S.; Kantrowitz, M.; Becker, T.; Samet, J. The New Mexico experiment. Educat. Innovat. Instit. Change Acad. Med., 1989, 64, 285-294.
[12]
Vazquez, M.J.; Casalderrey, M.; Concheiro, A. Atenolol release from hydrophilic matrix tablets with hydroxyl propyl methylcellulose (HPMC) mixtures as gelling agent: Effects of the viscosity of HTML mixture. Eur. J. Pharm. Sci., 2006, 4, 39-48.
[13]
Zuzarte, M.; Gonçalves, M.J.; Cavaleiro, C.; Canhoto, J.; Vale-Silva, L.; Silva, M.J.; Pinto, E.; Salgueiro, L. Chemical composition and antifungal activity of the essential oils of Lavandula viridis L’Her. J. Med. Microbiol., 2011, 60(Pt 5), 612-618.
[14]
Talukdar, M.M.; Plaizier-Vercammen, J. Evaluation of xanthan gum as a hydrophillic matrix for controlled release dosage form preparations. Drug Dev. Ind. Pharm., 2004, 19, 1037-1046.
[15]
Awika, J.M.; Rooney, L.W.; Wu, X.; Prior, R.L.; Cisneros-Zevallos, L. Screening methods to measure antioxidant activity of sorghum (sorghum bicolor) and sorghum products. J. Agric. Food Chem., 2003, 51(23), 6657-6662.
[16]
Jadhav, S.J.; Nimbalkar, S.S.; Kulkarni, A.D.; Madhavi, D.L. Food Antioxidants: Technological, Toxicological and Health Perspectives; Madhavi, D.L.; Deshpande, S.S; Salunkhe, D.K., Ed.; Marcel Dekker: New York, 1996, pp. 5-64.
[17]
Nielsen, I.L.F.; Haren, G.R.; Magnussen, E.L.; Dragsted, L.O.; Rasmussen, S.E. Quantification of anthocyanins in commercial black currant juices by simple high-performance liquid chromatography. Investigation of their pH stability and antioxidative potency. J. Agric. Food Chem., 2003, 51(20), 5861-5866.
[18]
Arnao, M.B.; Cano, A.; Hernández-Ruiz, J.; García-Cánovas, F.; Acosta, M. Inhibition by L-ascorbic acid and other antioxidants of the 2.2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) oxidation catalyzed by peroxidase: A new approach for determining total antioxidant status of foods. Anal. Biochem., 1996, 236(2), 255-261.
[19]
Thabrew, M.I.; Joice, P.D.; Rajatissa, W. A comparative study of the efficacy of Pavetta indica and Osbeckia octandra in the treatment of liver dysfunction. Planta Med., 1987, 53(3), 239-241.


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Article Details

VOLUME: 20
ISSUE: 8
Year: 2019
Page: [679 - 688]
Pages: 10
DOI: 10.2174/1389201020666190617165300
Price: $65

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