Impact of Curcumin on Traumatic Brain Injury and Involved Molecular Signaling Pathways

(E-pub Ahead of Print)

Author(s): Tahereh Farkhondeh, Saeed Samarghandian*, Babak Roshanravan, Leila Peivasteh-roudsari.

Journal Name: Recent Patents on Food, Nutrition & Agriculture

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Abstract:

Traumatic brain injury (TBI) is one of the main causes of mortality and morbidity worldwide with no suitable treatment. The present study was designed to review the present literature about the protective effects of curcumin and the underlying mechanism against TBI. All published English language papers from beginning to 2019 were selected in this study. The findings indicate that curcumin may be effective against TBI outcomes by modulating the molecular signaling pathways involved in oxidative stress, inflammation, apoptosis, and autophagy. However, more experimental studies should be done to identify all mechanisms involved in the pathogenesis of TBI. In conclusion, the present study confirmed the potential therapeutic impact of curcumin for treating TBI.

Keywords: curcumin, traumatic brain injury, inflammation, oxidative stress, apoptosis, autophagy

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(E-pub Ahead of Print)
DOI: 10.2174/2212798410666190617161523

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