Tricyclic Antidepressants (TCAs) are a group of the main category of antidepressant drugs,
which are commonly prescribed to treat major depressive disorder. Determination of TCA drugs is
very important for clinical and forensic toxicology, especially for therapeutic drug monitoring in various
biofluids. High Performance Liquid Chromatography (HPLC) is a well-established technique for
this purpose. A lot of progress has been made in this field since the past 10 years. Novel extraction
techniques, and novel materials for sample preparation, novel columns and novel applications of analysis
of various biofluids for the determination of TCAs in combination with other drugs are some typical
examples. Moreover, advances have been performed in terms of Green Analytical Chemistry principles.
Herein, we aim to discuss the developed HPLC methods that were reported in the literature for
the time span of 2008-2018.
Keywords: Tricyclic antidepressants, TCAs, HPLC, medicinal chemistry, biological fluids, sample preparation.
Kabir, A.; Furton, K.G. Fabric Phase Sorptive Extractors, United
States Patents and Trademark Oce. 2016.
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