Synthesis and In Vitro Antitumor Effect of New Vindoline-steroid Hybrids

Author(s): András Keglevich, Vivian Zsiros, Péter Keglevich*, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Erzsébet Mernyák, János Wölfling, László Hazai*.

Journal Name: Current Organic Chemistry

Volume 23 , Issue 8 , 2019

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Graphical Abstract:


10-Aminovindoline and 17-desacetylvindoline were coupled with 5α- dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines.

Keywords: Vinca alkaloids, vindoline, steroid, succinate linker, hybrid molecules, antitumor activity.

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Article Details

Year: 2019
Page: [959 - 967]
Pages: 9
DOI: 10.2174/1385272823666190614113218
Price: $58

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