10-Aminovindoline and 17-desacetylvindoline were coupled with 5α-
dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result,
four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new
hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer
and melanoma cell lines.
Keywords: Vinca alkaloids, vindoline, steroid, succinate linker, hybrid molecules, antitumor activity.
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