Clinical and Epidemiologic Features of Visceral Leishmaniasis in Children: A 6-year study from an Iranian referral hospital

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Author(s): Mohamadreza Abdolsalehi, Babak Pourakbari, Shima Mahmoudi, Mina Moradzadeh, Hossein Keshavarz, Setareh Mamishi.

Journal Name: Infectious Disorders - Drug Targets

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Background: Visceral leishmaniasis (VL) is an emerging zoonosis disease that is endemic in northwestern and southern part of Iran. This study aimed to evaluate the clinical characteristics and laboratory findings of the children with VL hospitalized at Children Medical Center Hospital (CMC), Tehran, Iran.

Methods: A retrospective study was performed based on studied medical records of children with a final diagnosis of VL from 2011 to 2016. For each patient demographic, clinical laboratory finding and treatment were examined.

Results: The clinical features of 17 children are examined and the most frequent symptoms were fever (94.1%, n=16/17), pallor, loss of appetite (76.5%, n=13/17), splenomegaly (82.4%, n=14/17) and hepatomegaly (58.8%, n=10/17). The most frequent laboratory abnormalities were hematological including anemia (94.1%, n=16/17), leukopenia (52.9%, n=9/17) and thrombocytopenia (70.5%, n=12/17). In order to detect anti-Leishmania antibodies, DAT was performed in 11 patients and 82% of them were positive (titers ≥ 1: 3200). In addition rK39 was done in 9 cases and 7 children (78%) had positive results. Direct parasitology consisting of presence of amastigotes of Leishmania in bone marrow aspirate (BMA) stained by Giemsa stain; was found in 9 patients (62.9%, among 13 children).

Conclusion: Leishmaniasis is regional disease, so that management and control of disease particularly in endemic area as well as detection of new emerging foci is recommended.

Keywords: Leishmaniasis, Children, Iran

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(E-pub Abstract Ahead of Print)
DOI: 10.2174/1871526519666190613123217
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