The aim of this paper is to establish guidelines for the management of extended-spectrum beta-lactamases (ESBL) associated prosthetic joint infections (PJI). This study reviewed 21 patients in the literature with documented ESBL associated PJI. Literature suggests patients with ESBL PJI being stratified into either early infections (<3 weeks) or late infections (>3 weeks), following which appropriate laboratory and imaging studies need to be completed. Favorable outcomes require a two-stage revision with an antibiotic impregnated spacer and a prolonged course of intravenous carbapenem antibiotic.
Keywords: ESBL, prosthetic joint infections, treatment
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