Ros-Mediated Induction of Apoptosis in Breast Cancer Cells
Pp. 113-121 (9)
Due to an excessive production of ROS production by the cell's loss of its
ability to metabolize, an oxidative stress is expressed. An excessive accumulation of
ROS alters not only the biochemical but also genetic and epigenetic mechanisms.
These changes could lead to cancer development. In previous studies, it was
determined that ROS plays a critical role and the therapy target has also been
discussed. So, throughout this manuscript, I aimed to review the role of ROS and its
associated signaling pathways in the initiation and progression and apoptosis of breast
cancer. This fine distinction of the ROS action depends not only on pro-apoptotic
agents and anti-apoptotic agents; ROS leads to the activation of several signaling
pathways but also on the duration, type, dosage (concentration) and site of ROS
generation and change gene expressions. This study will keep current on the relevant
mechanisms of ROS-mediated apoptosis and will guide future studies.
ROS, Oxidative Stress, Apoptosis, Capsase, Breast Cancer, MCF7
cells, MDA-MB-231 cells, anticancer drugs, Molecular mechanisms.
Beykent University, Vocational School, Pharmacy Services Program, Biochemistry Area, 34500, Istanbul, Turkey.