New Promises to Cure Cancer and Other Genetic Diseases/Disorders: Epi-drugs Through Epigenetics

Author(s): Yong-Tao Duan , Chetan B. Sangani* , Wei Liu , Kunjal V. Soni , Yongfang Yao* .

Journal Name: Current Topics in Medicinal Chemistry

Volume 19 , Issue 12 , 2019

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Graphical Abstract:


Abstract:

All the heritable alterations in gene expression and chromatin structure due to chemical modifications that do not involve changes in the primary gene nucleotide sequence are referred to as epigenetics. DNA methylation, histone modifications, and non-coding RNAs are distinct types of epigenetic inheritance. Epigenetic patterns have been linked to the developmental stages, environmental exposure, and diet. Therapeutic strategies are now being developed to target human diseases such as cancer with mutations in epigenetic regulatory genes using specific inhibitors. Within the past two decades, seven epigenetic drugs have received regulatory approval and many others show their candidature in clinical trials. The current article represents a review of epigenetic heritance, diseases connected with epigenetic alterations and regulatory approved epigenetic drugs as future medicines.

Keywords: Cancer, Genetic diseases, Epigenetics, DNA methylation, Histone modifications, Non-coding RNAs, Epi-drug.

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VOLUME: 19
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Year: 2019
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