Background & Objective: A direct and efficient approach for the synthesis of new series of
fused quinazolines with triazole, thiazole, benzimidazole and tetrazole has been preceded via the
reaction of quinazoline thione derivative with halogenated compounds or cyclocondensation of
arylidene of quinazoline derivative with heterocyclic amines. Also, dibenzo[b,e][1,4]thiazepine
derivatives was synthesized through the reaction of 2,6-bis-(2-chloro-benzylidene)-cyclohexanone
Methods: The structures of all new synthesized heterocyclic compounds were confirmed and discussed
on the bases of spectral data.
Results: The utility of the preparation and design of the above mentioned compounds has been shown
to be clear in the results of their antimicrobial activity which revealed that some derivatives have
potent activity exceeding or similar to the activity of the reference drugs.
Conclusion: The insertion of triazole or thiazole moieties to be fused with quinazoline ring helps to
enhance its antimicrobial activity.