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ISSN (Print): 1872-2105
ISSN (Online): 2212-4020

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Research Article

Cellulose Acetate Nanofibrous Membranes for Antibacterial Applications

Author(s): Zhipeng Ma, Xinghuan Lin and Xuehong Ren*

Volume 13, Issue 3, 2019

Page: [181 - 188] Pages: 8

DOI: 10.2174/1872210513666190603084519

Price: $65

Abstract

Backgrounds: N-halamine antibacterial materials have been extensively explored over the past few decades due to their fast inactivation of a broad spectrum of bacterial and rechargeability. Electrospun nanofibers loaded with N-halamines have gained great attention because of their enhanced antibacterial capability induced by the larger specific surface area. The patents on electrospun nanofibers (US20080679694), (CN2015207182871) helped in the method for the preparation of nanofibers.

Methods: In this study, a novel N-halamine precursor, 3-(3'-Chloro-propyl)-5,5-dimethylimidazolidine- 2,4-dione(CPDMH), was synthesized. Antimicrobial electrospun Cellulose Acetate (CA) nanofibers were fabricated through impregnating CPDMH as an antimicrobial agent into CA fibers by the bubble electrospinning. The surface morphologies of CA/CPDMH nanofibrous membranes were characterized by Scanning Electron Microscope (SEM).

Results: The chlorinated fibrous membranes (CA/CPDMH-Cl) exhibited effective antimicrobial activity against 100% of S. aureus and E. coli O157:H7 within 1 min and 5 min, respectively. The CA/CPDMH-Cl nanofibrous membranes showed good storage stability under the dark and excellent durability towards UVA light exposure. Meanwhile, the release of active chlorine from the chlorinated nanofibrous membranes was stable and safe. Besides, the addition of CPDMH could improve the mechanical property, and chlorination did not obviously affect the strength and elongation of the nanofibrous membranes.

Conclusion: CPDMH could endow the electrospun CA nanofibers with powerful, durable and regenerable antimicrobial properties. It will provide a continuous and effective method for health-care relative industrial application.

Keywords: Electrospun, Cellulose Acetate (CA), CPDMH, antibacterial, stability, polyurethane, N-halamine.

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[1]
Slaughter S, Hayden MK, Nathan C, et al. A comparison of the effect of universal use of gloves and gowns with that of glove use alone on acquisition of vancomycin-resistant enterococci in a medical intensive care unit. Ann Intern Med 1996; 125(6): 448-56.
[http://dx.doi.org/10.7326/0003-4819-125-6-199609150-00004] [PMID: 8779456]
[2]
Neely AN, Maley MP. Survival of enterococci and staphylococci on hospital fabrics and plastic. J Clin Microbiol 2000; 38(2): 724-6.
[PMID: 10655374]
[3]
Worley SD, Sun G. Biocidal polymers. Trends Polym Sci (Regul Ed) 1996; 11: 364-70.
[4]
Schild HG. Poly (N-Isopropylacrylamide) - Experiment, theory and application. Prog Polym Sci 1992; 17: 163-249.
[http://dx.doi.org/10.1016/0079-6700(92)90023-R]
[5]
Gebelein CG, Carraher CE. Biotechnology and bioactive polymers. Switzerland: Springer Nature 1994.
[http://dx.doi.org/10.1007/978-1-4757-9519-6]
[6]
Thomas V, Bajpai M, Bajpai SK. In situ formation of silver nanoparticles within chitosan-attached cotton fabric for antibacterial property. J Ind Text 2011; 40: 229-45.
[http://dx.doi.org/10.1177/1528083710371490]
[7]
Sun G, Xu X, Bickett JR, Williams JF. Durable and regenerable antibacterial finishing of fabrics with a new hydantoin derivative. Ind Eng Chem Res 2001; 40: 1016-21.
[http://dx.doi.org/10.1021/ie000657t]
[8]
Sun G, Xu X. Durable and regenerable antibacterial finishing of fabrics: Chemical structures. Text Chem Color 1999; 31: 31-40.
[9]
Sun G, Xu X. Durable and regenerable antibacterial finishing of fabrics: Biocidal properties. Text Chem Color 1998; 30: 26-30.
[10]
Chen Z, Luo J, Sun Y. Biocidal efficacy, biofilm-controlling function, and controlled release effect of chloromelamine-based bioresponsive fibrous materials. Biomaterials 2007; 28(9): 1597-609.
[http://dx.doi.org/10.1016/j.biomaterials.2006.12.001] [PMID: 17184837]
[11]
Liang J, Barnes K, Akdag A, et al. Improved antimicrobial siloxane. Ind Eng Chem Res 2007; 46: 1861-6.
[http://dx.doi.org/10.1021/ie061583+]
[12]
Lin J, Winkelman C, Worley SD, Broughton RM, Williams JF. Antimicrobial treatment of nylon. J Appl Polym Sci 2001; 81: 943-7.
[http://dx.doi.org/10.1002/app.1515]
[13]
Ren X, Kocer HB, Kou L, et al. Antimicrobial polyester. J Appl Polym Sci 2008; 109: 2756-61.
[http://dx.doi.org/10.1002/app.28126]
[14]
Luo J, Chen Z, Sun Y. Controlling biofilm formation with an N-halamine-based polymeric additive. J Biomed Mater Res A 2006; 77(4): 823-31.
[http://dx.doi.org/10.1002/jbm.a.30689] [PMID: 16575910]
[15]
Worley SD, Li F, Wu R, et al. A novel N-halamine monomer for preparing biocidal polyurethane coatings. Surf Coat Int B Coat Trans 2003; 86: 273-7.
[http://dx.doi.org/10.1007/BF02699499]
[16]
Chen S, Liu W. Preparation and characterization of surface-coated ZnS nanoparticles. Langmuir 1999; 15: 8100-4.
[http://dx.doi.org/10.1021/la9906875]
[17]
Dong A, Zhang Q, Wang T, Wang WW, Liu FQ, Gao G. Immobilization of cyclic N-Halamine on polystyrene-functionalized silica nanoparticles: Synthesis, characterization, and biocidal activity. J Phys Chem C 2010; 114: 17298-303.
[http://dx.doi.org/10.1021/jp104083h]
[18]
Dong Q, Cai Q, Gao Y, et al. Synthesis and bactericidal evaluation of imide N-halamine-loaded PMMA nanoparticles. New J Chem 2015; 39: 1783-91.
[http://dx.doi.org/10.1039/C4NJ01806K]
[19]
Fan XY, Ren XH, Huang TS, Sun YY. Cytocompatible antibacterial fibrous membranes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and quaternarized N-halamine polymer. Rsc Adv 2016; 6: 42600-10.
[http://dx.doi.org/10.1039/C6RA08465F]
[20]
Chakrabarty A, Singha NK. Tailor-made polyfluoroacrylate and its block copolymer by RAFT polymerization in miniemulsion; improved hydrophobicity in the core-shell block copolymer. J Colloid Interface Sci 2013; 408: 66-74.
[http://dx.doi.org/10.1016/j.jcis.2013.07.031] [PMID: 23953650]
[21]
Lin X, Fan X, Li R, et al. Preparation and characterization of PHB/PBAT–based biodegradable antibacterial hydrophobic nanofibrous membranes. Polym Adv Technol 2018; 29: 481-9.
[http://dx.doi.org/10.1002/pat.4137]
[22]
Liu Y, He JH. Bubble electrospinning for mass production of nanofibers. Int J Nonlin Sci Num 2007; 8: 393-6.
[23]
BioMimic fabrication of electrospun nanofibers with high-throughput. Chaos Solitons Fractals 2008; 37: 643-51.
[http://dx.doi.org/10.1016/j.chaos.2007.11.028]
[24]
Liu Y, He JH, Xu L, Yu JY. The principle of bubble electrospinning and its experimental verification. J Polym Eng 2008; 28: 55-65.
[25]
Dou H, Zuo BQ. A belt-like superfine film fabricated by bubble-electrospinning. Therm Sci 2013; 17: 1508-10.
[http://dx.doi.org/10.2298/TSCI1305508D]
[26]
Kong HY. HE JH. Superthin combined PVA-graphene film. Therm Sci 2012; 16: 560-1561.
[27]
Liu FJ, Dou H. A modified Young-Laplace equation for the bubble electrospinning considering the effect of humidi. Therm Sci 2013; 17: 629-30.
[http://dx.doi.org/10.2298/TSCI121229028L]
[28]
Yang R, He J, Xu L, Yu J. Bubble-electrospinning for fabricating nanofibers. Polymer (Guildf) 2009; 50: 5846-50.
[http://dx.doi.org/10.1016/j.polymer.2009.10.021]
[29]
Chen RX. Burst of a fast axially moving micro/nano jet. Bubbfil Nanotechnol 2014; 1: 13-23.
[30]
Ghaemi N, Madaeni SS, Alizadeh A, Rajabi H, Daraei P, Falsafi M. Effect of fatty acids on the structure and performance of cellulose acetate nanofiltration membranes in retention of nitroaromatic pesticides. Desalination 2012; 301: 26-41.
[http://dx.doi.org/10.1016/j.desal.2012.06.008]
[31]
Li R, Dou J, Jiang Q, et al. Preparation and antimicrobial activity of β-cyclodextrin derivative copolymers/cellulose acetate nanofibers. Chem Eng J 2014; 248: 264-72.
[http://dx.doi.org/10.1016/j.cej.2014.03.042]
[32]
Ren XH, Akdag A, Kocer HB, Worley SD, Broughton RM, Huang TS. N-Halamine-coated cotton for antimicrobial and detoxification applications. Carbohydr Polym 2009; 78: 220-6.
[http://dx.doi.org/10.1016/j.carbpol.2009.03.029]
[33]
Richter MF, Drown BS, Riley AP, et al. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature 2017; 545(7654): 299-304.
[http://dx.doi.org/10.1038/nature22308] [PMID: 28489819]
[34]
Li XL, Liu Y, Jiang ZM, Li R, Ren XH, Huang TS. Synthesis of an N-halamine monomer and its application in antimicrobial cellulose via an electron beam irradiation process. Cellulose 2015; 22: 3609-17.
[http://dx.doi.org/10.1007/s10570-015-0763-3]
[35]
Chen Z, Luo J, Sun Y. Biocidal efficacy, biofilm-controlling function, and controlled release effect of chloromelamine-based bioresponsive fibrous materials. Biomaterials 2007; 28(9): 1597-609.
[http://dx.doi.org/10.1016/j.biomaterials.2006.12.001] [PMID: 17184837]
[36]
Yu DN, Tian D, He JH. Snail-based nanofibers. Mater Lett 2018; 220: 5-7.
[http://dx.doi.org/10.1016/j.matlet.2018.02.076]
[37]
Liu YQ, Zhao L, He JH. Nanoscale multi-phase flow and its application to control nanofiber diameter. Therm Sci 2018; 22(1A): 43-6.
[http://dx.doi.org/10.2298/TSCI160826148L]
[38]
Tian D, Li XX, He JH. Self-assembly of macromolecules in a long and narrow tube. Therm Sci 2018; 22(4): 1659-64.
[http://dx.doi.org/10.2298/TSCI1804659T]
[39]
Liu YQ, Feng JW, Zhang CC, et al. Air permeability of nanofiber membrane with hierarchical structure. Therm Sci 2018; 22(4): 1637-43.
[http://dx.doi.org/10.2298/TSCI1804637L]
[40]
Tian D, Zhou CJ, He JH. Strength of bubble walls and the Hall-Petch effect in bubble-spinning. Text Res J 2019; 89(7): 1340-4.
[http://dx.doi.org/10.1177/0040517518770679]
[41]
Liu P, He JH. Geometrical potential: An explanation on of nanofibers wettability. Therm Sci 2018; 22(1A): 33-8.
[http://dx.doi.org/10.2298/TSCI160706146L]
[42]
Peng NB, Liu YQ, Xu L, et al. A Rachford-Rice like equation for solvent evaporation in the bubble electrospinning. Therm Sci 2018; 22(4): 1679-83.
[http://dx.doi.org/10.2298/TSCI1804679P]
[43]
Zhao L, Liu P, He JH. Sudden solvent evaporation in bubble electrospinning for fabrication of unsmooth nanofibers. Therm Sci 2017; 21(4): 1827-32.
[http://dx.doi.org/10.2298/TSCI160725075Z]
[44]
Liu LG, He JH. Solvent evaporation in a binary solvent system for controllable fabrication of porous fibers by electrospinning. Therm Sci 2017; 21: 1821-5.
[http://dx.doi.org/10.2298/TSCI160928074L]

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