Metabolic Imbalance and Vitamin D Deficiency in Type 1 Diabetes in the Algerian Population

Author(s): Esma Mihoubi, Rachida Raache*, Habiba Amroun, Malha Azzouz, Assia Galleze, Nesrine Zaabat, Abdelghani Aissou, Amina Ferhat, Hassiba Guettaf-Sadi, Amel Boutemeur, Zoulikha Aoudia, Aissa Boudiba, Chafia Touil-Boukoffa, Mohamed C. Abbadi, Nabila Attal.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 19 , Issue 8 , 2019

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Graphical Abstract:


Abstract:

Background: We aimed to assess Vitamin D levels in patients with Type 1 Diabetes (T1D) and to investigate the correlation between vitamin D and metabolic imbalance.

Material and Methods: For our study, we selected thirty-one patients with T1D without complications and fifty-seven healthy controls. Diabetic patients were diagnosed using the criteria of the World Health Organization/American Diabetes Association. Vitamin D, Parathyroid Hormone (PTH), insulin and C peptide assay were performed using chimilunescence. Glucose level, lipid profile, glycated haemoglobin (HbA1c) and ionogram were also analysed.

Results: Vitamin D, HbA1c and Gly levels were found to be significant in T1D patients than in controls (P<0.5). However, for PTH, no significant difference was observed (P > 0. 05) and the results show a non-significant difference of total cholesterol potassium, sodium, phosphor and calcium concentration averages.

Conclusion: Our results indicate that the deficiency of VD is associated with an increased risk of T1DM in Algerian population.

Keywords: Diabetes Type 1 (DT1), Parathyroid Hormone (PTH), Vitamin D, glycemic level, modulation, HbA1c.

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Article Details

VOLUME: 19
ISSUE: 8
Year: 2019
Page: [1172 - 1176]
Pages: 5
DOI: 10.2174/1871530319666190529113404
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