Isothermal Amplification Methods for the SNP Genotyping

Author(s): Somayeh Heidari Sharafdarkolaee, Pooria Gill*, Majid Motovali-Bashi, Fatemeh Heidari Sharafdarkolaee.

Journal Name: Current Molecular Medicine

Volume 19 , Issue 7 , 2019

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Abstract:

The demands for genotyping techniques with acceptable precision, accuracy, cost-effectiveness in high throughput formats made driving forces for continuous development of novel technologies. A wide range of mutation detection techniques based on polymerase chain reaction (PCR) have been introduced. The best alternatives were the isothermal amplification technologies that those did not require a thermal cycler. In this review, we aimed to describe the most known isothermal amplification techniques for SNP genotyping.

Keywords: Mutation detection, SNP, Genotyping, Isothermal amplification, Polymerase chain reaction, LAMP.

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Article Details

VOLUME: 19
ISSUE: 7
Year: 2019
Page: [461 - 472]
Pages: 12
DOI: 10.2174/1566524019666190527083947
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