Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine

Author(s): András Keglevich* , Áron Szigetvári , Miklós Dékány , Csaba Szántay , Péter Keglevich , László Hazai* .

Journal Name: Current Organic Chemistry

Volume 23 , Issue 7 , 2019

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Abstract:

An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives were coupled with triphenylphosphine, to afford the expected phosphonium salts. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated.

Keywords: Anticancer drugs, dimer Vinca alkaloids, vindoline, triphenylphosphine, phosphonium salts, antiproliferative activity.

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Article Details

VOLUME: 23
ISSUE: 7
Year: 2019
Page: [852 - 858]
Pages: 7
DOI: 10.2174/1385272823666190524083236
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