Background: Zinc oxide nanoparticles (ZnO NPs) are robustly used biomedicine. Moreover,
no study has been conducted to explore the consequence of green synthesis of ZnO NPs with Camellia
sinensis (green tea extract, GTE) on kidneys of rats treated with monosodium glutamate (MSG).
Methods: Therefore, the objective of the research was designed to explore the possible defensive effect
of GTE/ZnO NPs against MSG-induced renal stress investigated at redox and histopathological points.
Results: The levels of urea and creatinine increased as the effect of a high dose of MSG, in addition,
the myeloperoxidase and xanthine oxidase activates were elevated significantly with the high dose of
MSG. The levels of non-enzymatic antioxidants (uric acid, glutathione, and thiol) were decreased
sharply in MSG-treated rats as compared to the normal group.
Conclusion: The data displayed that GTE/ZnO NPs reduced the effects of MSG significantly by reduction
of the level peroxidation and enhancement intracellular antioxidant. These biochemical findings
were supported by histopathology evaluation, which showed minor morphological changes in the kidneys