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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Chloroquinoline-3-carbonitriles: Synthesis and Reactions

Author(s): Ramadan A. Mekheimer*, Mariam A. Al-Sheikh, Hanadi Y. Medrasi, Ghayah A. Bahatheg and Kamal U. Sadek

Volume 23, Issue 7, 2019

Page: [823 - 851] Pages: 29

DOI: 10.2174/1385272823666190516120946

Price: $65

Abstract

We herein describe the first review which aims to focus soberly the various synthetic methods and chemical reactions of chloroquinoline-3-carbonitrile derivatives. The reactions are subdivided into groups that cover reactions of chloro substituent at 2 or 4 and 2,4 positions, as well as cyano substituent at 3 position and reactions which involve both groups. Most types of reactions have been successfully applied and used in the production of biologically active compounds.

Keywords: Chloroquinoline-3-carbonitriles, synthesis, chemical reactions, biological activities, quinolines, heterocyclic alkaloids.

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