Chloroquinoline-3-carbonitriles: Synthesis and Reactions

Author(s): Ramadan A. Mekheimer*, Mariam A. Al-Sheikh, Hanadi Y. Medrasi, Ghayah A. Bahatheg, Kamal U. Sadek.

Journal Name: Current Organic Chemistry

Volume 23 , Issue 7 , 2019

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Graphical Abstract:


We herein describe the first review which aims to focus soberly the various synthetic methods and chemical reactions of chloroquinoline-3-carbonitrile derivatives. The reactions are subdivided into groups that cover reactions of chloro substituent at 2 or 4 and 2,4 positions, as well as cyano substituent at 3 position and reactions which involve both groups. Most types of reactions have been successfully applied and used in the production of biologically active compounds.

Keywords: Chloroquinoline-3-carbonitriles, synthesis, chemical reactions, biological activities, quinolines, heterocyclic alkaloids.

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Year: 2019
Page: [823 - 851]
Pages: 29
DOI: 10.2174/1385272823666190516120946
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