Monobactams: A Unique Natural Scaffold of Four-Membered Ring Skeleton, Recent Development to Clinically Overcome Infections by Multidrug-Resistant Microbes

(E-pub Abstract Ahead of Print)

Author(s): Abdel-Nasser El-Shorbagi*, Sachin Chaudhary.

Journal Name: Letters in Drug Design & Discovery

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Background: Monobactam antibiotics have been testified to demonstrate significant antibacterial activity especially in the treatment of infections by superbug microbes. Recently, much research has focused on the structural modifications, and new generation of this privileged natural scaffold.

Objective: Efforts have tried to discover the structure-antibacterial relationship of monbactams in order to avoid the aimless work involving the ongoing generated analogues. This review aims to summarize the current knowledge and development of monobactams as a broad-spectrum antibacterial scaffolds. The recent structural modifications that expand the activity, especially in the infections by resistant-strains, combinational therapies and dosing, as well as the possibility of cross-hypersensitivity/reactivity/tolerability with penicillins and cephalosporins will also be summarized and inferred. Different approaches will be covered with emphasis on chemical methods and structure-activity relationship (SAR), in addition to proposed mechanisms of action. Clinical investigation of monobactams tackling various aspects will not be missed in this review.

Conclusion: The conclusion includes the novels approaches, that could be followed to design new research projects and reduce the pitfalls in the future development of monobactams.

Keywords: Monobactams, Antibacterial, Multi-resistant strains, Penicillins, Cephalosporins, Structure-activity relationship, Clinical investigations

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(E-pub Abstract Ahead of Print)
DOI: 10.2174/1570180816666190516113202
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