1-Amidoalkyl-2-naphthols are an attractive group of organic compounds that can be converted to oxazine heterocycles and aminoalkyl naphthols. The derivatives of 1-amidoalkyl-2-naphthols have significant biological activities and acted as drug candidates. In this study, a simple, efficient, and operative method for the synthesis of 1-amidoalkyl-2-naphtholes in the presence of adipic acid as the catalyst is introduced. 1-Amidoalkyl-2-naphthols were synthesized via the three-component condensation reaction of 2-naphthol, acetamide/benzamide and various aldehydes under solvent-free conditions at 120 °C. Easy operation, acceptable reaction times, eco-friendly, availability of starting materials, easy separation of products, and high yields of products are significant results of this method. In this process, microwave or ultrasonic waves were not used to provide energy for the reaction.
Keywords: Adipic acid, 1-Amidoalkyl-2-naphtols, Aryl aldehyde, Green synthesis, Solvent-free, Three-component reaction
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