We present an efficient method for the synthesis of quinazolin-4(3H)-ones via Pd-catalyzed carbonylation-cyclization of N′-(2-bromophenyl)benzamidines. Chloroform cleanly generates CO under mild conditions. This method allows for the carbonylation-cyclization of N′-(2-bromophenyl)benzamidines in the presence of Pd(OAc)2 to give quinazolin-4(3H)-ones in good to excellent yields.
Keywords: Quinazolin-4(3H)-one, N′-(2-Bromophenyl)benzamidine, Chloroform, Palladium acetate, arbonylation
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