Thiazolidin-2,4-dione (TZD) possessing an active methylene constitute an important chemical
class of compounds for the development of new drugs. So, many scholars have synthesized these
derivatives as target molecules and evaluated their biological potential. Currently, some of the TZDs
are synthesized to treat human cancers stating high levels of PPARγ because it is expected that activation
of PPARγ arbitrates their anticancer activity because PPARγ ligands have recently been established
to affect differentiation, cell proliferation and apoptosis of different cell types. In the present review,
the synthesis of various derivatives of thiazolidine-2,4-diones, their mechanism of action and anticancer
activity have been highlighted.
Keywords: Anticancer, thiazolidin-2, 4-dione, PPARγ, chemical synthesis, thiazolidin-2, 4-diones (TZDs).
Rights & PermissionsPrintExport