Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology

Author(s): Anisa Dehghani , Hulya Karatas* .

Journal Name: Current Neuropharmacology

Volume 17 , Issue 10 , 2019

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Graphical Abstract:


Abstract:

Migraine, an extremely disabling neurological disorder, has a strong genetic component. Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers discover migraine pathophysiology, transgenic mice models harboring gene mutations identified in Familial Hemiplegic Migraine (FHM) patients have been generated. Studies in these FHM mutant mice models have shed light on the mechanisms of migraine and may aid in the identification of novel targets for treatment. More specifically, the studies shed light on how gene mutations, hormones, and other factors impact the pathophysiology of migraine. The models may also be of relevance to researchers outside the field of migraine as some of their aspects are relevant to pain in general. Additionally, because of the comorbidities associated with migraine, they share similarities with the mutant mouse models of epilepsy, stroke, and perhaps depression. Here, we review the experimental data obtained from these mutant mice and focus on how they can be used to investigate the pathophysiology of migraine, including synaptic plasticity, neuroinflammation, metabolite alterations, and molecular and behavioral mechanisms of pain.

Keywords: Familial hemiplegic migraine, mouse models, migraine with aura, cortical spreading depression, pathophysiology, neuroinflammation, treatment.

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Article Details

VOLUME: 17
ISSUE: 10
Year: 2019
Page: [961 - 973]
Pages: 13
DOI: 10.2174/1570159X17666190513085013
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