1,5-Benzodiazepines are considered some of the most vital classes of heterocyclic compounds
due to their amazing biological and varied pharmacological activities. They are regarded as
privileged structures and therefore have been striking synthetic targets for organic and medicinal
chemists over the last decade. This results in the exploration of various silica supported catalysts,
Lewis acids, organoacids, magnetic nanoparticles and other miscellaneous catalysts that have been
investigated till date for an efficient and green synthesis of 1,5-benzodiazepine and its derivatives.
The current review article primarily covers the one-pot green chemical synthesis of 1,5-
benzodiazepines using various novel catalysts. The main motive of this review is the assessment of
the literature on various catalysts along with their yield, reaction condition, and mechanism of action.
In the end, the entire catalysts are structured systematically into various Lewis acids, Bronsted organoacids,
supported catalysts, nanocatalysts, and miscellaneous catalysts and are presented in the
form of tables for quick ‘at a glance’ study of catalysts, their reaction condition, time taken, etc.