Roles of TRPM7 in Renal Ischemia-Reperfusion Injury

Author(s): Aifen Liu, Bin Yang*.

Journal Name: Current Protein & Peptide Science

Volume 20 , Issue 8 , 2019

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Graphical Abstract:


Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) that is a global health concern associated with high morbidity and mortality. So far, no specific interventions limit injury or improve recovery and survival. Transient receptor potential melastatin 7 (TRPM7), a bifunctional membrane protein, plays key roles in inflammation and cell death. However, the precise role and underlying mechanism of TRPM7 in IR-induced AKI have not been well defined. Herein, we reviewed the structure and function of TRPM7 as a non-selective ion channel, but Ca2+ and Mg2+-conducting, that mediated the elevation of cytosolic Ca2+ and Mg2+. We then comprehensively reviewed the mechanism of TRPM7 involved in the pathophysiology of renal IRI, including inflammatory response, apoptosis and necroptosis, renal microvasculature, as well as maladaptive fibrogenesis leading to chronic kidney disease (CKD). Our previous study has shown that the dynamic change and underlying mechanism of TRPM7 involving in inflammation and apoptosis in in vitro hypoxia/reoxygenation and in vivo renal IRI models. The association between TRPM7, inflammatory response and apoptosis, as well as related caspase-3, HMGB1 and Bax/Bcl-2 ratio, was also discussed. Disclosing the involvement of TRPM7 in renal IRI might provide new mechanistic insights for a potential biomarker as diagnostic and therapeutic target of AKI.

Keywords: TRPM7, ischemia-reperfusion injury, kidney, inflammation, apoptosis, necroptosis, fibrosis.

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Article Details

Year: 2019
Page: [777 - 788]
Pages: 12
DOI: 10.2174/1389203720666190507102948
Price: $58

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