Hemodynamic Changes of Hepatic & Renal vessels In Systemic Bacterial Infection with Fever in HCV Related Cirrhosis

(E-pub Abstract Ahead of Print)

Author(s): Eman Mohammed Helal, Mohamed Sharaf-Eldin, Abdel Raouf Abou El Azm, Nagwa Mansour Badr Eldin, Mohammed Mahmoud Dawoud , Sherief Abd-Elsalam*, Dina Hazem Ziada.

Journal Name: Infectious Disorders - Drug Targets

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Objectives: To study the hemodynamic changes of hepatic & renal vessels in systemic bacterial infection with fever in HCV related cirrhosis with possible complications.

Methods: Three groups of patients with systemic bacterial infection with fever were included in the study; group І included 15 patients with decompensated cirrhosis, group ІІ included 15 patients with compensated cirrhosis and group ІІІ included 10 patients without liver affection. Laboratory parameters and Doppler US of hepatic and renal vessels were evaluated during and after subsidence of fever in all patients.

Results: Forty patients were enrolled in this prospective study. There were 22 male and 18 female patients. In this study, the direction of blood flow in the portal and splenic veins was hepatopetal and the veins were non pulsatile in all cases with no change during and after subsidence of infection. There was no significant difference in portal or splenic vein diameter during and after subsidence of infection in the three studied groups. However, the mean values of portal and splenic veins peak velocities were significantly lower during infection in cirrhotic groups. The mean value of hepatic artery resistive index during fever was significantly higher than that after fever in cirrhotic groups. Renal resistive and pulsatility indices were significantly higher during fever in cirrhotic groups.

Conclusion: Systemic bacterial infection with fever can affect hepatic haemodynamics leading to aggravation of portal hypertension and increasing the risk of complications as variceal bleeding and hepatic encephalopathy and also can affect renal haemodynamics with risk of renal impairment.

Keywords: Hepatitis C virus; Cirrhosis; Encephalopathy; Portal hypertension; Hepatorenal syndrome.

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(E-pub Abstract Ahead of Print)
DOI: 10.2174/1871526519666190506102703
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