Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer

Author(s): Chang Gao, Ya-Nan Peng, Hai-Zhou Wang, Shi-Lin Fang, Meng Zhang, Qiu Zhao, Jing Liu*.

Journal Name: Current Pharmaceutical Design

Volume 25 , Issue 8 , 2019


Heat shock protein 90 (Hsp90) plays an essential role in various physiological and pathological processes. It activates client proteins to participate in tumor progression. Blocking Hsp90 could enable effective antitumor effects in many tumor types, such as multiple myeloma and colon cancer. Recently, it has motivated an interest in Hsp90 inhibitors that bind to the N-terminal or C-terminal ATP pocket as antitumor drugs. We reviewed the data from experimental and clinical trials on Hsp90 inhibitors in the treatment of different malignancies to explore and summarize their antitumor mechanisms.

Keywords: Heat shock protein 90, signaling pathway, client protein, ATPase, inhibitor, cancer treatment.

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Year: 2019
Page: [849 - 855]
Pages: 7
DOI: 10.2174/1381612825666190503145944
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