Sulfoxides are key scaffolds in the synthesis of pharmaceutically active molecules. A large number of sulfoxides are an indispensable ingredient in the structure or building of most of antibiotics, biological and natural products such as Modafinil, Adrafinil, CRL-40,941 or fladrafinil, Fipronil, Oxydemeton-methyl, Omeprazole, Pantoprazole, Lansoprazole and Rabeprazole. The oxidation of sulfides is the most common and most efficient strategy for the preparation of sulfoxides. In recent times, many protocols based on using transition metals have been reported for the oxidation of sulfides to the sulfoxides. In this paper, we summarized a nice category of reported protocols in literature for the oxidation sulfides to sulfoxides.