Anti-inflammatory, Antiulcer and Anticancer Activities of Saponin Isolated from the Fruits of Ziziphus jujuba

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Author(s): Ajay Chowdari M, Giles D*.

Journal Name: The Natural Products Journal

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Background: Ziziphus jujuba Mill was commonly used for its anti-inflammatory activity in traditional system of medicine.

Objective: The purpose of this study was to examine the isolates of methanolic extract from the fruits of Ziziphus jujuba Mill for its antiulcer, anti-inflammatory, and anticancer activity.

Method: Methanolic extracts of Ziziphus jujuba Mill were subjected to chromatography and eluted using ethyl acetate: methanol mixture and investigated for its structural features using IR, 1H NMR, 13C NMR and mass spectral data. The isolated compound was evaluated for its in vitro COX-2 inhibition studies, cytotoxicity studies, in vivo anti-inflammatory, antiulcer and anticancer activity.

Results: The spectral data revealed that the backbone of the isolate was 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl jujubogenin-20-O-(2,3,4-O-triacetyl)-α-L-rhamnopyranoside. The isolated compound showed significant reduction in inflammation and edema. Moderate anticancer activity was also observed for the isolate.

Conclusion: It was concluded that the isolated saponin possess moderate antiulcer, anti-inflammatory, and anticancer activity which could help in the identification of leads for the treatment of cancer-related inflammation.

Keywords: Anticancer, Anti-inflammatory, Antiulcer, Saponin, Ziziphus jujuba

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(E-pub Ahead of Print)
DOI: 10.2174/2210315509666190429145610
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