Ziziphus jujuba Mill was commonly used for its anti-inflammatory activity in traditional system of medicine.
The purpose of this study was to examine the isolates of methanolic extract from the fruits of Ziziphus jujuba Mill for its antiulcer, anti-inflammatory, and anticancer activity.
Methanolic extracts of Ziziphus jujuba Mill were subjected to chromatography and eluted using ethyl acetate: methanol mixture and investigated for its structural features using IR, 1H NMR, 13C NMR and mass spectral data. The isolated compound was evaluated for its in vitro COX-2 inhibition studies, cytotoxicity studies, in vivo anti-inflammatory, antiulcer and anticancer activity.
The spectral data revealed that the backbone of the isolate was 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl jujubogenin-20-O-(2,3,4-O-triacetyl)-α-L-rhamnopyranoside. The isolated compound showed significant reduction in inflammation and edema. Moderate anticancer activity was also observed for the isolate.
It was concluded that the isolated saponin possess moderate antiulcer, anti-inflammatory, and anticancer activity which could help in the identification of leads for the treatment of cancer-related inflammation.