Exosome: An Emerging Source of Biomarkers for Human Diseases

Author(s): Li Xu, Long-Fei Wu, Fei-Yan Deng*.

Journal Name: Current Molecular Medicine

Volume 19 , Issue 6 , 2019

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Abstract:

Exosomes are 30-120nm long endocytic membrane-derived vesicles, which are secreted by various types of cells and stably present in body fluids, such as plasma, urine, saliva and breast milk. Exosomes participate in intercellular communication. Recently accumulative studies have suggested that exosomes may serve as novel biomarkers for disease diagnosis and prognosis. Herein, we reviewed the biological features of exosomes, technologies for exosome isolation and identification, as well as progress in exosomal biomarker identification, highlighting the relevance of exosome to human diseases and significance and great potential in translational medicine.

Keywords: Exosome, Isolation, Biomarker, Protein, RNA, Diagnosis.

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Article Details

VOLUME: 19
ISSUE: 6
Year: 2019
Page: [387 - 394]
Pages: 8
DOI: 10.2174/1566524019666190429144310
Price: $65

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