Current Research and Use of Mesenchymal Stem Cells in the Therapy of Autoimmune Diseases

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Author(s): Youdong Chen, Qian Yu, Yifan Hu, Yuling Shi*.

Journal Name: Current Stem Cell Research & Therapy

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Mesenchymal Stem Cells (MSCs) represents a heterogenous group of self-renewal, multipotent non-hematopoietic stem cells, which display profound immunomodulatory functions and promising therapeutic effects. Autoimmune diseases, which result from aberrant immune response to self-antigens, can be detrimental to nearly all body tissues. With the advance in developing novel treatment, including biological agents, it is still impossible to cure autoimmune disorders. Recent studies demonstrate a remarkable therapeutic effectiveness of MSCs towards a wide array of autoimmune diseases. In this review, the immunomodulatory influence of MSCs over immune cells and the application of MSCs transplantation in treating autoimmune diseases are highlighted.

Keywords: mesenchymal stem cell, autoimmune diseases, psoriasis, RA, umbilical cord

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(E-pub Ahead of Print)
DOI: 10.2174/1574888X14666190429141421
Price: $95