Background: Benzimidazole is the fused heterocyclic aromatic compound. It is an essential
pharmacophore and privileged structure for the development of new drug molecules. These are
bioactive molecules present in various anthelmintic drugs such as albendazole, mebendazole, parbendazole,
Methods: Benzimidazole derivatives are synthesized by reaction between orthophenylene diamine
and anthranillic acid followed by acetylation in the presence of acetic anhydride. Finally, the acetylated
products undergo Claisen-Schimdt condensation with various substituted benzaldehydes to produce
corresponding benzimidazole derivatives or chalcones. Both conventional and microwave irradiation
technology are followed to get the titled compounds. The titled compounds are screened for
their anticonvulsant and neurotoxicity activity.
Results: By the help of microwave synthesis, the yield of product was increased in less reaction time.
So, it follows Green chemistry approach by making above reactions eco-friendly. Some of the compounds
exhibited significant anticonvulsant activity as compared to standard drug.
Conclusion: In the present investigation, we have synthesized novel benzimdazole derivatives with
chalone moiety to improve the biological activity. The compounds were obtained under microwave
reaction with high yield in a short reaction time.