Recent Patents and Discovery of Anti-inflammatory Agents from Marine Source

Author(s): Simrin Kapoor, Namrata Nailwal, Maushmi Kumar, Kalyani Barve*.

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery

Volume 13 , Issue 2 , 2019

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Background: Inflammation has become pathology in the majority of the prevalent diseases such as diabetes, atherosclerosis, epilepsy and neurodegenerative disorders. Anti-inflammatory drugs work wonder in all these conditions, where the patient has become refractory to standard treatment. However, available anti-inflammatory agents have side effects associated with chronic use, thus if we could develop safe and efficacious molecules, quality of health care provided will improve. Since plant sources have been extensively explored, the focus needs to be shifted on the alternative natural sources of anti-inflammatory agents. Water bodies especially the sea and ocean are under investigation to find agents which can tackle inflammation.

Objective: This article reviews anti-inflammatory agents obtained from five types of marine organisms namely microalgae, sea cucumber, mussels, sponges and corals.

Methods: A literature search was conducted using PubMed/Science Direct with keywords marine organisms, inflammation, marine sponges, sea cucumber, mussels, corals and microalgae. Patents were searched using the key terms inflammation, marine agents from,,,, jsp and

Results: Literature and current patents have revealed applications of anti-inflammatory agents from marine organisms in pharmaceuticals and cosmeceuticals. These agents are used to treat inflammatory disorders ranging from minor allergy to chronic conditions like rheumatoid arthritis. Marine waste is also a valuable resource for nutraceuticals and anti-inflammatory agents.

Conclusion: The findings reveal that marine organisms could be a promising source of novel antiinflammatory agents. However, further investigations are suggested for the isolation and identification of bioactive, exploring the mechanism of action and evaluating the efficacy in various inflammatory conditions.

Keywords: Corals, inflammation, marine sponges, microalgae, mussels, patents, sea cucumber.

Suleria H, Osborne S, Masci P, Gobe G. Marine-based nutraceutical: An innovative trend in the food and supplement industries. Mar Drugs 2015; 13(10): 6336-51.
Jimeno J, Faircloth G, Sousa-Faro J, Scheuer P, Rinehart K. New marine derived anticancer therapeutics- A journey from the sea to clinical trials. Mar Drugs 2004; 2(1): 14-29.
Skropeta D. Deep-sea natural products. Nat Prod Rep 2008; 25(6): 1131-66.
Faulkner DJ. Chemical riches from the ocean. Chem Br 1995; 39(1): 680-4.
Kim SK. Marine Pharmacognosy: Trends and Applications. 1st ed. CRC Press: Boca Raton 2013.
Malve H. Exploring the ocean for new drug developments: Marine pharmacology. J Pharm Bioallied Sci 2016; 8(2): 83-91.
Van der Westhuyzen A, Frolova L, Kornienko A, VanOtterlo WAL. The rigidins: Isolation, bioactivity, and total synthesis-novel pyrrolo [2,3- d] pyrimidine analogues using multicomponent reactions. J Med Chem 2013; 56(17): 6886-900.
Lindequist U. Marine-derived pharmaceuticals- Challenges and opportunities. Biomol and Ther 2016; 24(6): 561-71.
Suleria H, Masci P, Addepalli R, Chen W, Gobe G, Osborne S. In vitro anti-thrombotic and anti-coagulant properties of blacklip abalone (Haliotis rubra) viscera hydrolysatein RAW. Anal Bioanal Chem 2017; 409(17): 4195-205.
Suleia H, Masci P, Addepalli R, Gobe G, Osborne S. In vitro anti-inflammatory activities of blacklip abalone (Haliotis rubra) in RAW 264.7 macrophages. Food and Agric Immunol 2017; 28(4): 711-24.
Dysghlovoy S, Honecker F. Marine compound and cancer: 2017 Updates. Mar Drugs 2018; 16(2): 41.
Ferrero-Miliani L, Nielsen O, Andersen P, Girardin S. Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1 generation. Clin Exp Immunol 2007; 147(2): 227-35.
Kemp W, Burns D, Brown T. From Pathology: The Big Picture. InInflammation and Repair. 1st ed. New York: McGraw Hill Professional 2017; pp. 13-22.
González Y, Torres-Mendoza D, Jones G, Fernandez P. Marine diterpenoids as potential anti-inflammatory agents. Mediators Inflamm 2015; 2015263543
Litalien C, Beaulieu P. In Hardman JG, Limbird LE, Gilman AG, Eds. The Pharmacological Basis of Therapeutics. New York: McGraw- Hill Education 2011; 41-72.
Kijjoa A, Sawangwong P. Drugs and cosmetics from the sea. J Pharm Bioallied Sci 2018; 8(2): 83-91.
Lauritano C, Andersen JH, Hansen E, Albrigtsen M, Escalera L, Esposito F, et al. Bioactivity screening of microalgae for antioxidant, anti-inflammatory, anticancer, anti-diabetes, and antibacterial activities. Front Mar Sci 2016; 3(68)
Freitas H. Chlorella vulgaris as a source of essential fatty acids and micronutrients: A brief commentary. TOPSJ 2017; 10: 92-9.
Suleria H, Gobe G, Masci P, Osborne S. Marine bioactive compounds and health promoting perspectives; Innovation pathways for drug discovery. Trends Food Sci Technol 2016; 50: 44-55.
Sibi G, Rabina S. Inhibition of pro-inflammatory mediators and cytokines by Chlorella vulgaris extracts. Pharmacognosy Res 2016; 8(2): 118-22.
Tadashi M, Haruko T, Hideki M, Hiroko Y. Marine microalgae. Adv Biochem Eng Biotechnol 2005; 96: 165-88.
Carolina de Los Reyes. Maria JO, Azahara Rodriguez-L, Elena T, Virginia M, Eva Z. Molecular characterization and anti-inflammatory activity of galactosylglycerides and galactosylceramides from the microalga Isochrysis galbana. J Agric Food Chem 2016; 64(46): 8783-94.
Rodríguez-Luna A, Talero E, Terencio M, González-Rodríguez M, Rabasco A, de los Reyes C, et al. Topical application of glycolipids from Isochrysis galbana prevents epidermal hyperplasia in mice. Mar Drugs 2018; 16(1)E2
Hibberd D. Notes on the taxonomy and nomenclature of the algal classes Eustigmatophyceae and Tribophyceae (synonym Xanthophyceae). Bot J Linn Soc 1981; 82(2): 93-119.
Lubián L, Montero O, Moreno-Garrido I, et al. Nannochloropsis (Eustigmatophyceae) as source of commercially valuable pigments. J Appl Phycol 2000; 12: 249-55.
Assaf S, Yael C, Tamar B. Regulation of fatty acid composition by irradiance level in the Eustigmatophyte Nannochloropsis sp. J Phycol 1989; 25(4): 686-92.
Ma XN, Chen TP, Yang B, Liu J, Chen F. Lipid production from Nannochloropsis. Mar Drugs 2016; 14(4): 61.
El-Feky AM, Aboulthana WM, Abo El-Khair B. El-Sayed, Ibrahim NE. Chemical and therapeutic study of Nannochloropsis oculata on spleen of Streptozotocin induced diabetes in rats. Der Pharma Chem 2017; 9(18): 36-43.
Keisuke T, Takashi Y, Hiromi T. Anti-inflammatory compounds. JP2015174850 2010).
Hui Z, Zunting P, Chunchao H. Undaria pinnatifida (wakame): A seaweed with pharmacological properties. Sci Int 2014; 2: 32-6.
Khan MN, Cho JY, Lee MC, Kang JY, Park NG, Fujii H, et al. Isolation of two anti-inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida. J Agric Food Chem 2007; 55(17): 6984-8.
Winget RR. Anti-inflammatory compositions containing eicosapentaenoic acid bearing monogalactosyldiacylglycerol and methods relating thereto. WO1994024984 (1994).
Winget RR. Anti-inflammatory compositions containing monogalactosyldieicosapentaenoyl glycerol and methods of relating thereto. US5620962 (1997).
James R, Lane D, David F, Kelly G. Methods and compositions for modulating hair growth or regrowth. US20070036742 (2007).
Yong-Ki H. An extract of Undaria pinnatifida having antiinflammatory activity. KR100807758 (2008).
John AM, Hill WS, Moerck RE. Composition and method to improve blood lipid profiles and reduce Low Density Lipoprotein (LDL) per-oxidation in humans using algae based oils and astaxanthin. US20140205627 (2014).
Zanella L, Pertelle P. Extracts of Nannochloropsis sp. and their applications. CN107148264 (2017).
Toralf S, Jorg B, Laurent M. Fatty acid desaturases, elongases, elongation components and uses thereof. WO2006008401 (2016).
Santhi LS, Prasad Talluri VSSL, Nagendra SY, Radha Krishna E. Bioactive compounds from marine sponge associates: Antibiotics from Bacillus sp. Nat Prod Chem Res 2017; 5: 266.
Stamatios P, Thomais V, Athanasios V. Bioactive natural substances from marine sponges: New developments and prospects for future pharmaceuticals. Nat Prod Chem Res 2013; 1: 3.
Anjum K, Abbas SQ, Shah SA, Akhter N, Batool S, Hassan SS. Marine sponges as a drug treasure. Biomol Ther 2016; 24(4): 347-62.
Kumar MS, Adki KM. Marine natural products for multi-targeted cancer treatment: A future insight. Biomed Pharmacother 2018; 105: 233-45.
Mayer AM, Aviles E, Rodríguez AD. Marine sponge Hymeniacidon sp. amphilectane metabolites potently inhibit rat brain microglia thromboxane B2 generation. Bioorg Med Chem 2012; 20(1): 279-82.
Elena C, Anna Maria M, Chiara L, Angelo F, Genoveffa N, Adele C, et al. Immuno-modulatory and anti-inflammatory effects of dihydrogracilin A, a terpene derived from the marine sponge Dendrilla membranosa. Int J Mol Sci 2017; 18(8): 1643.
Di X, Oskarsson JT, Omarsdottir S, Freysdottir J, Hardardottir I. Lipophilic fractions from the marine sponge Halichondria sitiens decrease secretion of pro-inflammatory cytokines by dendritic cells and decrease their ability to induce a Th1 type response by allogeneic CD4+ T cells. Pharm Biol 2017; 55(1): 2116-22.
Jacobs RS, Faulkner DJ. Manoalide an anti-inflammatory analgesic marine natural product. US4447445 (1984).
Philip BD, Gerald W. Method for measuring anti-inflammatory properties of a composition. US4605618 (1986).
McConnell OJ, Gabriel S, Robert J. Novel use as antiinflammatory agents for bis-heterocyclic compounds and pharmaceutical compositions thereof. WO1994019343 and WO1994019343 (1994).
Jacobs RS, Shirley P, Sarath G, Amy W. Anti-neurogenic inflammatory compounds and compositions and methods of use thereof. WO1998018466 (1998).
Wolfgang S, Joerg K, Muller WEG, Dieter S, Maria S. Method for isolating sponge collagen and producing nanoparticulate collagen, and the use thereof. WO2001064046 (2002).
Nakamura K, Nakamura K. Skin care preparation for external use. JP2004250357 (2004).
Bringmann G, Gerhard L, Muchlbacher J, Muller WEG, Schaumann K, Steffens S. New compounds sorbicillactone A and derivatives, useful as antitumor, antiviral and anti-inflammatory agents, obtained e.g. by culturing Penicillium fungi. DE10238257 (2004).
What are corals? Available at: https:/ als (Accessed on: September 1, 2018).
Coral and Coral Reefs. Available at: seasense/coral/ (Accessed on: September 2, 2018).
Coral Reefs and Medicine. Available at: ourinitiatives/habitats/ oceanscoasts/explore/coral-reefs-and-medicine.xml (Accessed on: September 2, 2018).
Cooper E, Hirabayashi K, Strychar K, Sammarco P. Corals and their potential applications to integrative medicine. J Evid Based Complementary Altern Med 2014; 2014
Sung P, Chen B, Lin M, Hwang T, Wang W, Sheu J, et al. Excavatoids E and F: Discovery of two new briaranes from the cultured octocoral Briareum excavatum. Mar Drugs 2009; 7: 472-82.
Lin Y, Lin S, Feng C, Chen P, Su Y, Li C, et al. Anti-inflammatory and analgesic effects of the marine-derived compound excavatolide B isolated from the culture-type formosan gorgonian Briareum excavatum. Mar Drugs 2015; 13(5): 2559-79.
Horng Sheu J. Sun Yang, N., Chi Wei, W., Yao Huang, C. Pharmaceutical uses of diterpene excavatolide B from a coral or an analogue thereof. US8530513 (2013).
Bingzhen S, Weixian W, Zhihong W, Yishan W, Taiyan Z, Yinbin Z. Coral extract, extraction method and use thereof, and coral extract skin care product. CN104095883 (2014).
Lai K, You W, Lin C, El-Shazly M, Liao Z, Su J. Anti-inflammatory cembranoids from the soft coral Lobophytum crassum. Mar Drugs 2017; 15(10): 327.
Miyamoto T, Miyamoto S. Coral-derived therapeutic agent for inflammation and allergic disease. JP2010222307 (2010).
Reddy NS, Goud TV, Venkateswarlu Y. Seco-sethukarailin, a novel diterpenoid from the soft coral Sinulariadissecta. J Nat Prod 2002; 65(7): 1059-60.
Nguyen P, Nguyen H, Nguyen X, Bui H, Tran H, Nguyen T, et al. Steroidal constituents from the soft coral Sinularia dissecta and their inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Bulletin. JKCS 2013; 34(3): 949-51.
Faulkner DJ, Venkateswarlu KY, Yadav J, Raghavan V. Rameswaralide and rameswaralide derivatives. WO2000027839 (2001).
Rahman MA, Yusoff F. M. Sea cucumber fisheries: Market potential, trade, utilization and challenges for expanding the production in the South-East Asia. IJACEBS 2017; 4(1): 26-30.
Ratih P, Zainal A. Medicinal and health benefit effects of functional sea cucumbers. J Tradit Complement Med 2018; 8(3): 341-51.
Sara B, Farooq A, Nazamid S. High-value components and bioactives from sea cucumbers for functional foods- A review. Mar Drugs 2011; 9(10): 1761-805.
Magdalena M, Stefaniak V, Varsha AK, María G, Gudrun M, Olafur F, et al. Bioactive effect of sulphated polysaccharides derived from orange-footed sea cucumber (Cucumaria frondosa) toward THP-1 macrophages. Bioact Carbohydr Dietary Fibre 2017; 12: 14-9.
Collin PD. Sea cucumber carotenoid lipid fraction products and methods of use. US6399105 (2002).
Tae RK, Chang TO, Dong HB, Jong HK, Joon S, Jong HL, et al. Effects on skin of Stichopus japonicus viscera extracts detected with saponin including Holothurin A: Down-regulation of melanin synthesis and up-regulation of neocollagenesis mediated by ERK signaling pathway. J Ethnopharmacol 2018; 226: 73-81.
Himaya SW, Ryu B, Quian ZJ, Kim SK. Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages. Environ Toxicol Pharmacol 2010; 30(1): 68-75.
Se-Kwon K, Bomi R, Himaya SWA, Jung-Ji C. Sea cucumber extra having anti-inflammatory and anti-inflammatory composition comprising same. KR20120028153 (2012).
Soo-Bum P, Hyung-Min H, Won-Jong Y, Gil Nam K, Hwan Jung J, Wook Jae L. A composition as anti-inflammatory medicine and a composition for an anti-cancer medicine. KR101166677 (2012).
Yanmei Z, Huirong Z, Lifeng G. Traditional Chinese medicine formulation for treating cervicitis and preparation method of traditional Chinese medicine formulation. CN103830517 (2014).
Isostichopus badionotus. Available at: details/180519/0 (Accessed on: September 20, 2018).
Leticia OC, Nuvia KM, Juan J, Acevedo F, Marili PS, Jorge M, et al. Sea cucumber (Isostichopus badionotus) body-wall preparations exert anti-inflammatory activity in vivo. PharmaNutrition 2018; 6(2): 74-80.
Collin PD. Tissue fractions of sea cucumber for the treatment of inflammation. US5770205 (1998).
Yong-Woo L, Young-Ki K, Mi-Ae K, Yang-Sook O. Fermented sea cucumber extract and its cosmetic usage. KR20140016461 (2014).
Bayne B. Marine mussels. J Mar Biol Assoc U K 2009; 56(4): 1056.
Mussel. Available at: (Accessed on: 1 Sep. 2018).
Importance of mussels. Available at: (Accessed on: Sep 1, 2018).
Grienke U, Silke J, Tasdemir D. Bioactive compounds from marine mussels and their effects on human health. Food Chem 2016; 148(1): 48-60.
Wang F, Fu Y, Cai W, Sinclair A, Li D. Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (Mytilus coruscus) in mice with dextran sulphate sodium-induced colitis. Mar Drugs 2014; 12(2): 568-88.
Ogawa A, Yamashita H. Skin care preparation for external use. JP2003335651 (2002).
Eun-Kyung K, Hyun-Jung KP. Anti-inflammatory composition comprising enzymatic hydrolysates of Mytilus coruscus. KR20120049043 (2012).
Pleissner D, Eriksen N, Lundgreen K, Riisgård H. Biomass composition of blue mussels, Mytilus edulis, is affected by living site and species of ingested microalgae. Int Sch Res Notices 2012; 2012
Kim Y, Ahn C, Je J. Anti-inflammatory action of high molecular weight Mytilus edulis hydrolysates fraction in LPS-induced RAW264.7 macrophage via NF-κB and MAPK pathways. Food Chem 2016; 202(1): 9-14.
Macrides T, Kalafatis N. Anti-inflammatory preparation. WO1996005164 (1996).
Macrides T, Kalafatis N. Super-critical lipid extract from mussels having anti-inflammatory activity. US6083536 (2000).
Bui LM, Bierer TL, Hodge J, Bektash R, Blackwood G. Pet food for maintenance of joint health and alleviation of arthritic symptoms in companion animals. US6596303 (2003).
Davis PF. Mussel extract composition with enhanced antiinflammatory activity. WO2006052150 (2006).
Wakimoto T, Kondo H, Nii H, Kimura K, Egami Y, Oka Y, et al. Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus. Proc Natl Acad Sci USA 2011; 108(42): 17533-7.
Treschow A, Hodges L, Wright P, Wynne P, Kalafatis N, Macrides T. Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol 2007; 147(4): 645-56.
Halpern M. Anti-inflammatory effect on stabilized lipid extract of Perna canaliculus (Lyprinol®). Allerg Immunol (Paris) 2000; 32(7): 272-8.
Kendall RV. Composition comprising an extract of Perna canaliculus, methylsulfonylmethane and glucosamine. WO2001001976 (2020).
Chandler A. combinations of hyaluronic acid and polyunsaturated fatty acids. US20070270376 (2007).
Chandler A. Treatment for asthma and arthritis and other inflammatory diseases. US20080234362 (2008).
Jae-Gun K, Ki-Ho K, Dong-Hyun K, et al. Cosmetic composition containing extracts of Perna canaliculus. KR100852864 (2008).
Min G. Mussel adhesive protein product and use thereof for inhibiting mucosal inflammation. WO2017028025 (2015).
Min G. Mussel adhesive protein product, and use thereof in preventing and suppressing neuronal inflammation. WO2017088177 (2015).
Minatell JA, Hill WS, Rudi E, Moerck RE. Composition and method to alleviate joint pain using algae based oils. US9238043 (2016).
Toralf S, Jorg B, Laurent M. Fatty acid desaturases, elongases, elongation components and uses thereof. WO2006008401 (2016).
Houwen L, Weihua J. Sesquiterpene quinone compound dysiherbols A, and preparation method and application thereof. CN105541562 (2016).
Renxuzn Z. Method for preparing functional raw material from Stichopus japonicas. CN106137896 (2016).
Zanella L, Pertelle P. Extracts of Nannochloropsis sp. and their applications. CN107148264 (2017).
Min G. Mussel adhesive protein product and use thereof for inhibiting soft tissue inflammation. WO2017181977 (2017).
Bingda C, Chengxun Z, Youxiang P, Mingshu J, Shunyu C. Composition comprising extract of mixture of Undaria pinnatifida sporophylls and ascidian shells for treating atopicdermatitis. CN104379155 (2018).
Suleria H. Marine processing waste- in search of bioactive molecules. Nat Prod Chem Res 2016; 4e118

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Year: 2019
Page: [105 - 114]
Pages: 10
DOI: 10.2174/1872213X13666190426164717

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