The Effect of Vitamin D Supplementation on Clinical Outcomes of Asthmatic Children with Vitamin D Insufficiency

Author(s): Rasoul N. Kalmarzi, Sivan Ahmadi, Ramesh Rahehagh, Asadollah Fathallahpour, Behzad Khalafi, Hajar Kashefi, Daem Roshani, Rama N. Zaryan, Shilan Mohamadi, Wesam Kooti*.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 20 , Issue 1 , 2020

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Graphical Abstract:


Abstract:

Background: The extensive impacts of vitamin D on the immune system has gathered the attention of scholars in last years. In this regard, studies about vitamin D and incidence of asthma have showed various results. The aim of this study was to evaluate the effect of vitamin D supplements on clinical outcomes in asthmatic children with vitamin D insufficiency.

Materials & Methods: This before-after interventional study was conducted on all asthmatic children who attended the Be'sat Hospital, Iran. Serum levels of 25(OH)D, asthma severity and pulmonary function tests before and after therapeutic prescription of vitamin D were evaluated. Serum levels of 25(OH)D were measured by enzyme-linked immunosorbent assay.

Results: The mean age of the samples was 10.69±9.78 years and 39 subjects (57.4%) were male. The primary mean level of serum 25(OH)D (18.21±8.22, ng/mL) has significantly (p<0.05) increased after treatment (35.45±9.35, ng/mL). Also, asthma severity, forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC indicators were significantly (p<0.05) increased after treatment.

Conclusion: We can conclude that therapeutic prescription of vitamin D is very effective in improving the clinical status of asthmatic children.

Keywords: Vitamin D, Asthma, Children, Insufficiency, Clinical Outcomes, Iran.

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VOLUME: 20
ISSUE: 1
Year: 2020
Page: [149 - 155]
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DOI: 10.2174/1871530319666190426161809
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