Background: The extensive impacts of vitamin D on the immune system has gathered the
attention of scholars in last years. In this regard, studies about vitamin D and incidence of asthma have
showed various results. The aim of this study was to evaluate the effect of vitamin D supplements on
clinical outcomes in asthmatic children with vitamin D insufficiency.
Materials & Methods: This before-after interventional study was conducted on all asthmatic children
who attended the Be'sat Hospital, Iran. Serum levels of 25(OH)D, asthma severity and pulmonary
function tests before and after therapeutic prescription of vitamin D were evaluated. Serum levels of
25(OH)D were measured by enzyme-linked immunosorbent assay.
Results: The mean age of the samples was 10.69±9.78 years and 39 subjects (57.4%) were male. The
primary mean level of serum 25(OH)D (18.21±8.22, ng/mL) has significantly (p<0.05) increased after
treatment (35.45±9.35, ng/mL). Also, asthma severity, forced expiratory volume in 1 second (FEV1),
forced vital capacity (FVC), and FEV1/FVC indicators were significantly (p<0.05) increased after
Conclusion: We can conclude that therapeutic prescription of vitamin D is very effective in improving
the clinical status of asthmatic children.