The Role of the Sodium-taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) in Related Liver Disease

Author(s): Xiaoyang Lu, Lin Liu, Wenya Shan, Limin Kong, Na Chen, Yan Lou*, Su Zeng.

Journal Name: Current Drug Metabolism

Volume 20 , Issue 5 , 2019

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Abstract:

Background: Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts. They have emerged as promising drug targets in related liver disease.

Methods: We reviewed the literature published over the last 20 years with a focus on NTCP and BSEP.

Results: This review summarizes the current perception about structure, function, genetic variation, and regulation of NTCP and BSEP, highlights the effects of their defects in some hepatic disorders, and discusses the application prospect of new transcriptional activators in liver diseases.

Conclusion: NTCP and BSEP are important proteins for transportation and homeostasis maintenance of bile acids. Further research is needed to develop new models for determining the structure-function relationship of bile acid transporters and screening for substrates and inhibitors, as well as to gain more information about the regulatory genetic mechanisms involved in the processes of liver injury.

Keywords: NTCP and BSEP, expression and function, genetic variants, liver disease, transcriptional regulation, substrates and inhibitors.

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Article Details

VOLUME: 20
ISSUE: 5
Year: 2019
Page: [377 - 389]
Pages: 13
DOI: 10.2174/1389200220666190426152830
Price: $58

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