Molecular Mechanisms Underlying Cancer Preventive and Therapeutic Potential of Algal Polysaccharides

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Author(s): Soraya Sajadimajd, Saeideh Momtaz, Pouya Haratipour, Fardous F. El-Senduny, Amin Iran Panah, Jafar Navabi, Zhaleh Soheilikhah*, Mohammad Hosein Farzaei*, Roja Rahimi.

Journal Name: Current Pharmaceutical Design

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Abstract:

Background: Algal polysaccharides and oligosaccharide derivatives have been shown to possess a variety of therapeutic potentials and drug delivery applications. Algal polysaccharides contain sulfated sugar monomers derived from seaweed including brown, red, and green microalgae. Here in this review, the recent progress of algal polysaccharides’ therapeutic applications as anticancer agents, as well as underlying cellular and molecular mechanisms were investigated. Moreover, recent progress in the structural chemistry of important polysaccharides with anticancer activities was illustrated.

Methods: Electronic databases including “Scopus”, “PubMed”, and “Cochrane library” were searched using the keywords “cancer”, or “tumor”, or “malignancies” in title/abstract, along with “algae”, or “algal” in the whole text until July 2018. Only English language papers were included.

Results: The most common polysaccharides involved in cancer management were sulfated polysaccharides, Fucoidans, Carageenans, and Ulvan from different species of algae that have been recognized in vitro and in vivo. The underlying anticancer mechanisms of algal polysaccharides included induction of apoptosis, cell cycle arrest, modulation of transduction signaling pathways, suppression of migration and angiogenesis, as well as activation of immune responses and antioxidant system. VEGF/VEGFR2, TGFR/Smad/Snail, TLR4/ROS/ER, CXCL12/CXCR4, TGFR/Smad7/Smurf2, PI3K/AKT/mTOR, PBK/TOPK, and β-catenin/Wnt are among the main cellular signaling pathways which have a key role in preventive and therapeutic effect of algal polysaccharides against oncogenesis.

Conclusion: Algal polysaccharides play a crucial role in the management of cancer and may be considered the next frontier in pharmaceutical research. Further well-designed clinical trials are mandatory to evaluate the efficacy and safety of algal polysaccharides in patients with cancer.

Keywords: algal polysaccharide, sulfated polysaccharide; anticancer; antioxidant; antitumor; anti-inflammatory

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(E-pub Ahead of Print)
DOI: 10.2174/1381612825666190425155126
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