Background: Nanoparticle technologies used for human administration must be
designed to interact with a living host environment. The idea about bioinspired smart drug
delivery carriers includes the development of biocompatible nanomaterials which can be
further loaded with the drug for specific targeted drug delivery applications.
Objective: Biosmart nanosystems are used for several applications in the delivery of drugs
and pharmaceuticals for their therapeutic applications like biological markers, diagnostic
purposes such as imaging applications and also for gene therapy. Thus, the bioinspired
nanocarriers are capable of carrying biologically active molecules to the target sites. This
bioinspired nanosystem constitutes of lipids, polymers and biomaterials which utilizes various
responsive sensors for targeted drug delivery systems. However, external conditions
such as heat, light, magnetic or electric field and ultrasounds, along with temperature, altered
pH and ionic strength can affect the bioinspired smart nanosystem for drug delivery.
Conclusion: The present review focuses on challenges for the development of bioinspired
smart nanocarriers for the management of various disorders.