In recent years, the synthesis of quinoline scaffold using various methodological
devices has attracted considerable attention in synthetic chemist community. The most feasible
method to serve this purpose is Aza-Diels-Alder reaction which provides flexibility and diversity
in the synthesis of quinoline decorated with different functionalities over the scaffold.
Diversity in this functionality improvises the susceptibility of the quinoline scaffold for various
protein targets. This review encompasses multifactorial aspects of Aza-Diels-Alder reaction
as well as provides insights into the synthetic schemes for quinoline scaffold.
Keywords: Aza-Diels-Alder, quinoline, catalysis, povarov, diastereoselective, multicomponent.
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