Relationship Between Hormonal Mechanisms of Diabetes Mellitus and Hypothyroidism Post-Bariatric Surgery

Author(s): Lucas G. Goes, Camila da Luz Eltchechem, Jessica Wouk, Carlos R.M. Malfatti, Luiz A. da Silva*.

Journal Name: Current Diabetes Reviews

Volume 16 , Issue 3 , 2020

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Abstract:

Background: Obesity, diabetes mellitus may be related to the health, the relationship and the physiological capacity of the production of thyroid hormones (TH), triiodothyronine (T3) and thyroxine (T4).

Objectives: The main aims of this review are to describe the relationship between obesity, appetite, weight management, hormonal mechanisms of diabetes mellitus and hypothyroidism post-bariatric surgery.

Methodology: An in-depth literature search was conducted to identify scientific studies, which analyzed the correlation between diabetes mellitus and hypothyroidism post-bariatric surgery.

Results: Bariatric surgery decreases hypothyroidism, reduces the need for pharmacological action (such as levothyroxine), controls the weight and body fat and increases the sensitivity to leptin and insulin.

Conclusion: The reduction of the stomach and intestine by bariatric surgery is an evolutionary and beneficial action, because it may lead to a drastic decrease on numbers of conditions such as diabetes, obesity, hypothyroidism, and others. Thus, new studies should also focus on patients’ post-operatory conditions, such as lifetime, regulation and functioning of organs after reduced nutrition, and consumption and delivery of nutrients to health maintenance.

Keywords: Metabolism, hormones, obesity, hypothyroidism, diabetes mellitus, post-bariatric surgery, patients.

[1]
2 diabetes. Diabetes, UK: Diabetic Medicine 2011. Dixon JB, Zimmet P, Alberti KG. Bariatric surgery: an IDF statement for obese Type
[2]
Mechanick JI, Youdim A, Jones DB, et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient—2013 update: Cosponsored by American associa-tion of clinical endocrinologists, the obesity society, and American society for metabolic & bariatric surgery. Obesity (Silver Spring, Md) 2013; 21(0 1): S1-27.
[3]
Santos LP, Ong KK, Santos IS. Matijasevich, Barros AJD. Effects of dietary intake patterns from 1 to 4 years on BMI z-score and body shape at age of 6 years: a prospective birth cohort study from Brazil. Eur J Nutr 2018; 17: 3-4.
[http://dx.doi.org/10.1007/s00394-018-1720-3] [PMID: 29774385]
[4]
Purnell JQ, Johnson GS, Wahed AS, et al. Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes for 2 years after Roux-en-Y gastric bypass. Diabetologia 2018; 61(5): 1142-54.
[http://dx.doi.org/10.1007/s00125-018-4553-y] [PMID: 29428999]
[5]
Bischoff SC, Boirie Y, Cederholm T, et al. Towards a multidisciplinary approach to understand and manage obesity and related diseases. Clin Nutr 2017; 36(4): 917-38.
[http://dx.doi.org/10.1016/j.clnu.2016.11.007] [PMID: 27890486]
[6]
Lin HC, Tsao LI. Living with my small stomach: The experiences of post-bariatric surgery patients within 1 year after discharge. J Clin Nurs 2018; 27(23-24): 4279-89.
[http://dx.doi.org/10.1111/jocn.14616] [PMID: 29989270]
[7]
Bétry C, Challan-Belval MA, Bernard A, et al. Increased TSH in obesity: Evidence for a BMI-independent association with leptin. Diabetes Metab 2015; 41(3): 248-51.
[http://dx.doi.org/10.1016/j.diabet.2014.11.009] [PMID: 25541439]
[8]
Knudsen N, Laurberg P, Rasmussen LB, et al. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J Clin Endocrinol Metab 2005; 90(7): 4019-24.
[http://dx.doi.org/10.1210/jc.2004-2225] [PMID: 15870128]
[9]
Nagel A, Spinneker A, Neuhäuser-Berthold M. Association of thyroid-stimulating hormone with resting energy expenditure in euthyroid elderly subjects: a cross-sectional study. Ann Nutr Metab 2016; 68(1): 12-8.
[http://dx.doi.org/10.1159/000441625] [PMID: 26555616]
[10]
Pucci E, Chiovato L, Pinchera A. Symposium 8. Thyroid function and iodothyronine and peripheral action and metabolism: Thyroid and lipid metabolism. Int J Obes 2000; 24: S109-12.
[http://dx.doi.org/10.1038/sj.ijo.0801292]
[11]
Koritschoner NP, Alvarez-Dolado M, Kurz SM, et al. Thyroid hormone regulates the obesity gene tub. EMBO Rep 2001; 2(6): 499-504.
[http://dx.doi.org/10.1093/embo-reports/kve107] [PMID: 11415982]
[12]
Chikunguwo S, Brethauer S, Nirujogi V, et al. Influence of obesity and surgical weight loss on thyroid hormone levels. Surg Obes Relat Dis 2007; 3(6): 631-5.
[http://dx.doi.org/10.1016/j.soard.2007.07.011] [PMID: 18023816]
[13]
Korner J, Inabnet W, Febres G, et al. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass. Int J Obes 2009; 33(7): 786-95.
[http://dx.doi.org/10.1038/ijo.2009.79] [PMID: 19417773]
[14]
Vincent RP, Ashrafian H, le Roux CW. Mechanisms of disease: the role of gastrointestinal hormones in appetite and obesity. Nat Clin Pract Gastroenterol Hepatol 2008; 5(5): 268-77.
[http://dx.doi.org/10.1038/ncpgasthep1118] [PMID: 18382432]
[15]
Guidone C, Manco M, Valera-Mora E, et al. Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery. Diabetes 2006; 55(7): 2025-31.
[http://dx.doi.org/10.2337/db06-0068] [PMID: 16804072]
[16]
Rodovalho S, Rachid B, De-Lima-Junior JC, et al. Impairment of body mass reduction-associated activation of brown/beige adipose tissue in patients with type 2 diabetes mellitus. Int J Obes 2017; 41(11): 1662-8.
[http://dx.doi.org/10.1038/ijo.2017.152] [PMID: 28669988]
[17]
Buchwald H, Oien DM, Schieber DJ, Bantle JP, Connett JE. Partial ileal bypass affords protection from onset of type 2 diabetes. Surg Obes Relat Dis 2017; 13(1): 45-51.
[http://dx.doi.org/10.1016/j.soard.2016.01.025] [PMID: 27262236]
[18]
Pearce EN. Thyroid hormone and obesity. Curr Opin Endocrinol Diabetes Obes 2012; 19(5): 408-13.
[http://dx.doi.org/10.1097/MED.0b013e328355cd6c] [PMID: 22931855]
[19]
Feldt-Rasmussen U. Thyroid and leptin. Thyroid 2007; 17(5): 413-9.
[http://dx.doi.org/10.1089/thy.2007.0032] [PMID: 17542671]
[20]
Patel CA, Acharya SR. Energy homeostasis and obesity: The therapeutic role of anorexigenic and orexigenic peptide. Int J Pept Res Ther 2018; 1-14.
[21]
Karamanakos SN, Vagenas K, Kalfarentzos F, Alexandrides TK. Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study. Ann Surg 2008; 247(3): 401-7.
[http://dx.doi.org/10.1097/SLA.0b013e318156f012] [PMID: 18376181]
[22]
Preiato VL, Vicennati V, Garelli S, Pagotto U. Neuroendocrinology of Energy Homeostasis. Hypothalamic-Pituitary Diseases 2017; pp. 1-24.
[23]
Pérez-Pérez A, Vilariño-García T, Fernández-Riejos P, Martín-González J, Segura-Egea JJ, Sánchez-Margalet V. Role of leptin as a link between metabolism and the immune system. Cytokine Growth Factor Rev 2017; 35: 71-84.
[http://dx.doi.org/10.1016/j.cytogfr.2017.03.001] [PMID: 28285098]
[24]
Spranger J, Meyer-Schwickerath R, Klein M, Schatz H, Pfeiffer A. TNF-alpha level in the vitreous body. Increase in neovascular eye diseases and proliferative diabetic retinopathy. Med Klin (Munich) 1995; 90(3): 134-7.
[PMID: 7723714]
[25]
Cummings DE, Overduin J, Foster-Schubert KE. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004; 89(6): 2608-15.
[http://dx.doi.org/10.1210/jc.2004-0433] [PMID: 15181031]
[26]
Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interven-tions: Explanation and elaboration. BMJ 2009. 21 339: b2700.


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Article Details

VOLUME: 16
ISSUE: 3
Year: 2020
Page: [200 - 203]
Pages: 4
DOI: 10.2174/1573399815666190417145440
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